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Book Cover
E-book
Author Kalter, Harold.

Title Teratology in the twentieth century : congenital malformations in humans and how their environmental causes were established / Harld Kalter
Edition 1st ed
Published Amsterdam ; Boston : Elsevier, 2003

Copies

Description 1 online resource (pages 132-290)
Contents Cover -- Teratology in the Twentieth Century -- Copyright Page -- Contents -- PREFACE -- CHAPTER 1. INTRODUCTORY MATTERS -- Coincidental discoveries -- Early genetic studies -- CHAPTER 2. DEFINITIONS -- Introduction: styles -- A small parenthesis -- Congenital means present at birth -- Malformations: abnormalities of structure -- Recognition of malformations -- Major and minor malformations -- Minor malformations and variants -- CHAPTER 3. CLASSIFICATION -- Introduction: why classify -- Classification by cause -- Classification by type -- Classification by pathogenesis -- Nomenclature -- Taxonomic innovations -- The developmental field concept -- CHAPTER 4. FREQUENCY -- Introduction: early findings -- Difficulties of establishing frequency -- A matter of names -- How often do malformations happen? -- A definite definition -- An aside -- Why investigate malformation frequency -- Ascertainment -- Underestimating frequency -- Overestimating frequency -- Biological factors -- Miscellaneous factors -- CHAPTER 5. EARLY HUMAN STUDIES -- Introduction: the principal objective -- X-irradiation -- Rubella -- Other infectious diseases -- Problems regarding intrauterine infection -- Intrauterine infection in animals -- CHAPTER 6. PIONEERING WORKS -- Irradiation studies not appreciated -- Vitamin deficiency -- CHAPTER 7. EARLY EXPERIMENTS -- Introduction: new needs and ideas -- Principles of teratology -- Vitamin A and diaphragmatic hernia -- Power of genetics -- Basis of diaphragmatic hernia -- Early investigators -- Trypan blue -- Hypoxia -- A little break: Down syndrome -- Cortisone studies and by-products -- A variety of experiments -- Vitamin antimetabolites -- CHAPTER 8. NEW CHALLENGES -- Infant mortality and malformations -- Teratology conferences -- The Teratology Society -- CHAPTER 9. THALIDOMIDE -- The event -- The thalidomide syndrome -- The revelation -- Thalidomide: safety and sales -- Toxicity in adults -- Thalidomide in the USA -- Thalidomide's teratogenic mechanism -- Dose- and time-response relations -- Animal studies with thalidomide -- Postscript: was anyone to blame? -- The future? -- CHAPTER 10. TESTING FOR TERATOGENICITY -- Proposals for drug testing -- The procedure -- The consequence -- The dose-response curve -- Teratogens and mutagens -- CHAPTER 11. TERATOLOGICAL DETOURS -- Bendectin -- Blighted potatoes -- Female sex hormones -- Diethylstilbestrol -- CHAPTER 12. SURVEILLANCE OF CONGENITAL MALFORMATIONS -- Introduction: fears and demands -- Surveillance and monitoring -- Monitoring's limited abilities -- CHAPTER 13. EPIDEMIOLOGY OF CONGENITAL MALFORMATIONS -- The classical method -- Epidemiology of malformation communities -- Familial studies -- Pyloric stenosis -- Clefts of the lip and palate -- Neural tube defects -- CHAPTER 14. HUMAN DISEASE AS TERATOGEN -- Phenylketonuria -- Insulin-dependent diabetes mellitus -- Hyperthermia -- CHAPTER 15. ENVIRO
Summary This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment
Notes "Reprinted from the journal: Neurotoxicology and teratology, vol. 25, issue 2 (2003)"--T.p.verso
Bibliography Includes bibliographical references (pages 256-282) and index
Notes Print version record
Subject Teratology -- History -- 20th century
Teratology -- history
History, 20th Century
MEDICAL -- Evidence-Based Medicine.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Diseases.
MEDICAL -- Internal Medicine.
MEDICAL -- Clinical Medicine.
Teratology
Genre/Form History
Form Electronic book
ISBN 9780444513649
0444513647
9780080542355
0080542352