| Description |
1 online resource (1 PDF file (viii, 67 pages : illustrations)) |
| Series |
Synthesis lectures on integrated systems physiology : from molecules to function ; #4 |
|
Colloquium series on integrated systems physiology ; #4. 2154-5626
|
| Contents |
1. Introduction -- 2. General characteristics of platelets -- Overview -- Platelet granules -- Alpha granules -- Dense granules -- Lysosomes -- Platelet adhesion molecules -- P-selectin -- Glycoprotein Ib/IX/V (GPIb/IX/V) -- Glycoprotein IIb/IIIa (GP IIb/IIIa) -- Collagen receptors -- G-protein-coupled receptors -- Thrombin -- Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) -- Prostanoids -- 3. Adhesion to Subendothelium Following Vascular Injury -- von Willebrand factor (vWF) -- Collagen -- Other Subendothelial Components -- Endogenous Mechanisms Preventing Platelet Adhesion to Endothelium -- Nitric Oxide -- Prostacyclin -- Ecto-adenosine diphosphatase (ADPase) -- Endothelial Surface Layer -- Mechanisms of Platelet Adhesion to Endothelium -- Endothelial P-Selectin-Dependent Mechanisms -- Endothelial vWF-Dependent Mechanisms -- Other Mechanisms -- 4. Platelet Aggregation -- Mechanisms of Platelet Aggregation -- Monitoring of Platelet Aggregation -- Ex Vivo Monitoring: Platelet Aggregometry -- In Vivo Monitoring of Platelet Aggregation -- 5. Platelet Recruitment and Blood Coagulation -- Role of Platelets -- Role of Platelet-Leukocyte Interactions -- 6. Arterial, Venous, and Microvascular Hemostasis/Thrombosis -- Venous Thrombosis -- Endothelial Injury -- Hypercoagulability -- Stasis -- Coexistence of Virchow's Triad Components: Cancer and Thrombosis -- Arterial Thrombosis -- Microvascular Thrombosis -- 7. Summary |
| Summary |
Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions |
| Bibliography |
Includes bibliographical references |
| Notes |
English |
| Subject |
Blood platelets.
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Blood -- Coagulation.
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Blood Platelets -- physiology
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Hemostasis -- physiology
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Thrombosis -- physiopathology
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Microcirculation -- physiology
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Blood Platelets
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Blood Coagulation
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Blood -- Coagulation
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Blood platelets
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| Form |
Electronic book
|
| Author |
Thiagarajan, Perumal.
|
| ISBN |
9781615040391 |
|
1615040390 |
|
9781615040407 |
|
1615040404 |
|
