| Description |
1 online resource (xiv, 259 pages) : illustrations (some color) |
| Series |
Progress in molecular and subcellular biology, 1611-6119 ; 46 |
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Progress in molecular and subcellular biology ; 46
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| Contents |
Marine toxins : an overview / Nobuhiro Fusetani and William Kem -- Conotoxins : molecular and therapeutic targets / Richard J. Lewis -- Sodium channel inhibiting marine toxins / Lyndon E. Llewellyn -- Sea anemone toxins affecting potassium channels / Sylvie Diochot and Michel Lazdunski -- Ligands for ionotropic glutamate receptors / Geoffrey T. Swanson and Ryuichi Sakai -- Marine toxins potentially affecting neurotransmitter release / Frédéric A. Meunier, César Mattei, and Jordi Mogló -- Toxins affecting actin filaments and microtubules / Shin-ya Saito -- Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors / Hirota Fujiki and Masami Suganuma |
| Summary |
Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Marine toxins.
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Marine Toxins
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Biomedical Research
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MEDICAL -- Toxicology.
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Biomedical Research.
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Marine toxins.
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Science des matériaux.
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Chimie.
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Marine toxins
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Toxin
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Meer
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Toxines marines.
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| Form |
Electronic book
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| Author |
Fusetani, Nobuhiro, 1943-
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Kem, William.
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| ISBN |
9783540878957 |
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3540878955 |
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