| Description |
1 online resource : illustrations (chiefly color) |
| Series |
Developmental biology ; Book #1 |
|
Colloquium series on developmental biology ; #1.
|
| Contents |
880-01 AP Genes -- bHLH Proteins -- ETS Genes -- Fox Genes -- Homeobox Genes -- Hox Genes -- Lim Genes -- Pax Genes -- POU Domain Genes -- RAR/RXR Genes -- Smad Genes -- Sox Genes -- Zinc Finger Genes -- Other Miscellaneous Genes |
|
880-01/(S 2.2.3 Zebrafish AP-2α Mutants2.2.4 Xenopus AP-2a; 2.2.5 Regulation of AP-2; 2.2.6 AP-2 Targets; 2.2.7 AP-2 Binding Sites; 2.2.8 AP-2 as an NC Marker; 2.3 AP-2b (Tcfap2b); 2.4 AP-2g (Tcfap2c); 2.5 AP-2d (Tcfap2d) AND AP-2e (Tcfap2e); chapter 3 bHLH Proteins; 3.1 Ascl1; 3.1.1 Ascl1 in the Sympathoadrenal Lineage; 3.1.2 Regulation of Ascl1 by BMP, cAMP, and Notch Signaling; 3.1.3 Ascl1 Interaction with Other Transcription Factors and Targets; 3.1.4 Ascl1 in Human Disease; 3.2 Hand1; 3.3 Hand2; 3.3.1 Hand2 in the Pharyngeal Arches and Derivatives; 3.3.2 Hand2 in the Heart |
| Summary |
"The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecified, nonmigratory population to a wide array of dynamic, differentiated cell types--some of which retain stem cell characteristics presumably to replenish these derivatives--requires a complex network of molecular switches to control the gene programs giving these cells their defining structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specific transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state." |
| Analysis |
Neural crest |
|
Transcription |
|
Regulation |
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Differentiation |
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Pax |
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Fox |
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Sox |
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Hox |
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bHLH |
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Zinc finger |
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Homeobox |
| Bibliography |
Includes bibliographical references |
| Notes |
English |
|
Online resource; title from resource home page (NCBI Bookshelf, viewed December 27, 2013) |
| Subject |
Neural crest.
|
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Genetic transcription.
|
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Embryology.
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Neural Crest -- embryology
|
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Transcription Factors -- metabolism
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Embryonic Development -- genetics
|
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Gene Expression Regulation, Developmental
|
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Neurulation -- genetics
|
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Transcription, Genetic
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Neural Crest
|
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SOCIAL SCIENCE -- Anthropology -- Physical.
|
|
Embryology.
|
|
Genetic transcription.
|
|
Neural crest.
|
| Form |
Electronic book
|
| Author |
Labosky, Patricia A., author.
|
| ISBN |
9781615040490 |
|
1615040498 |
|
