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Title TNF pathophysiology : molecular and cellular mechanisms / volume editors, G. Kollias, P.P. Sfikakis
Published Basel, Switzerland ; New York : Karger, ©2010


Description 1 online resource (vii, 215 pages) : illustrations
Series Current directions in autoimmunity, 1422-2132 ; v. 11
Current directions in autoimmunity ; v. 11.
Contents Cellular mechanisms of TNF function in models of inflammation and autoimmunity / Apostolaki, M. [and others] -- Transcriptional control of the TNF gene / Falvo, J.V., Tsytsykova, A.V., Goldfeld, A.E. -- Posttranscriptional regulation of TNF mRNA : a paradigm of signal-dependent mRNA utilization and its relevance to pathology / Stamou, P., Kontoyiannis, D.L. -- Role of TNF in pathologies induced by nuclear factor kB deficiency / Vlantis, K., Pasparakis, M. -- Type I interferon : a new player in TNF signaling / Yarilina, A., Ivashkiv, L.B. -- T cells as sources and targets of TNF : implications for immunity and autoimmunity / Chatzidakis, I., Mamalaki, C. -- TNF-a : an activator of CD4+FoxP3+TNFR2+regulatory T cells / Chen, X., Oppenheim, J.J. -- TNF and bone / David, J.-P., Schett, G. -- TNF-a and obesity / Tzanavari, T., Giannogonas, P., Karalis, K.P. -- TNF in host resistance to tuberculosis infection / Quesniaux, V.F.J. [and others] -- The first decade of biologic TNF antagonists in clinical practice : lessons learned, unresolved issues and future directions / Sfikakis, P.P
Summary TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Tumor necrosis factor -- Pathophysiology
Tumor Necrosis Factors -- immunology
Tumor Necrosis Factors -- physiology
Transcription, Genetic -- immunology
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Kollias, G. (George)
Sfikakis, P. P. (Petros P.)
ISBN 9783805593847
Other Titles Tumor necrosis factor pathophysiology