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Book Cover
Author Dannenberg, Arthur M., author

Title Pathogenesis of human pulmonary tuberculosis : insights from the rabbit model / Arthur M. Dannenberg
Published Washington, D.C. : ASM Press, ©2006
Online access available from:
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Description 1 online resource (xiv, 453 pages) : illustrations
Series Monograph, ASM Press
Monograph, ASM Press
Contents Stages in the pathogenesis of human and rabbit tuberculosis -- Types of human pulmonary tuberculosis -- Liquefaction of caseous foci and cavity formation -- Delayed-type hypersensitivity, cell-mediated immunity, and antibodies in tuberculosis -- Macrophages and other cells in tuberculous lesions -- Structural components of tuberculous lesions -- Microvascular density in tuberculous lesions -- Early pulmonary lesions in rabbits -- Macrophage turnover, division, and activation in tuberculous lesions -- Lurie's pulmonary Tubercle-count method -- Natural airborne infection -- Response of rabbits to inhaled tubercle bacilli including BCG-- Characteristics of resistance and susceptibility to tuberculosis in Lurie's inbred rabbits -- Comparisons of tuberculosis in rabbits, mice, and guinea pigs -- Effects of cortisone and adrenocorticotropic hormone on tuberculosis -- Effects of estrogen, chorionic gonadotropin, and thyroid hormone on tuberculosis -- Effects of whole-body X-irradiation on tuberculosis -- Cytokine production in primary BCG lesions -- Cytokine production in reinfection bcg lesions and in tuberculin reactions -- Vascular adhesion molecules in tuberculous lesions -- Principles and guidelines for developing better tuberculosis vaccines -- Characteristics of rabbit BCG lesions and efficacies of BCG and mycobacterium microti vaccines
Summary This work, authored by a noted and experienced expert in the field, examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the rabbit model. Tuberculosis in the rabbit most closely resembles that found in humans, including caseous necrosis, liquefaction, and cavity formation with bronchial spread of the disease
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Lurie, Max B. (Max Bernard), 1893-1966.
Tuberculosis -- Animal models.
Tuberculosis -- Pathophysiology.
Models, Animal.
Mycobacterium bovis -- pathogenicity.
Tuberculosis, Pulmonary -- physiopathology.
Tuberculosis, Pulmonary -- microbiology.
Form Electronic book
LC no. 2006021123
ISBN 1555815685 (electronic bk.)
9781555815684 (electronic bk.)