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E-book

Title Target discovery and validation : reviews and protocols / edited by Mouldy Sioud
Published Totowa, N.J. : Humana Press, ©2007

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Description 1 online resource (2 volumes) : illustrations
Series Methods in molecular biology, 1064-3745 ; 360-361
Methods in molecular biology (Clifton, N.J.) ; v. 360-361
Contents v. 1. Emerging strategies for targets and biomarker discovery -- v. 2. Emerging molecular targets and treatment options -- v. 2. Emerging molecular targets and treatment options
Summary Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products. Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic. Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Tumor markers.
Biochemical markers -- Therapeutic use
DNA microarrays.
Drug targeting.
Drugs -- Design.
Molecular pharmacology.
Antimitotic agents.
Antineoplastic agents.
Antineoplastic Agents
Drug Design
Biomarkers, Tumor
Drug Delivery Systems
Antimitotic Agents
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
DNA microarrays.
Drug targeting.
Drugs -- Design.
Molecular pharmacology.
Antineoplastic agents.
Drug Design.
Tumor Markers, Biological.
Tumor markers.
Biochemical markers -- Therapeutic use.
Antineoplastic agents
Antimitotic agents
DNA microarrays
Drug targeting
Drugs -- Design
Molecular pharmacology
Tumor markers
Genre/Form Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Sioud, Mouldy.
ISBN 1588296563
9781588296566
1588298906
9781588298904
9781588296566
1597451657
9781597451659
1597452084
9781597452083