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Title Extracellular targeting of cell signaling in cancer : strategies directed at MET and RON receptor tyrosine kinases / edited by James W. Janetka, Roseann Benson
Edition First edition
Published Hoboken, NJ : John Wiley and Sons, 2018
Online access available from:
Wiley Online Library Books    View Resource Record  


Description 1 online resource
Contents Discovery and function of the HGF/MET and the MSP/RON kinase signaling pathways in cancer / Silvia Benvenuti, Melissa Milan, and Paolo Comoglio -- The role of HGF/MET and MSP/RON signaling in tumor progression and resistance to anticancer therapy / Lidija Klampfer, Ben Yaw Owusu -- HGF activator (HGFA) and its inhibitors HAI-1 and HAI-2 : key players in tissue repair and cancer / Hiroaki Kataoka and Takeshi Shimomura -- Physiological functions and role of matriptase in cancer / Thomas E. Hyland, Karin List, and Fausto A. Varela -- The cell-surface, transmembrane serine protease hepsin : discovery, function and role in cancer / Denis Belitskin, Juha Klefström, Shishir Pant, and Topi Tervonen -- Targeting HGF with antibodies as an anticancer therapeutic strategy / Donald Bottaro, Dinuka M De Silva, and Arpita Roy -- MET and RON receptor tyrosine kinases as therapeutic antibody targets for cancer / Ling Liu, Mark Wortinger, Jonathan Tetreault, and Nick Loizos -- Inhibitory antibodies of the proteases HGFA, matriptase, and hepsin / Daniel Kirchoffer, Robert Lazarus, and Charles Eigenbrot -- Inhibitors of the growth-factor activating proteases matriptase, hepsin and HGFA : strategies for rational drug design and optimization / Robert Galemmo, James Janetka -- Cyclic peptide serine protease inhibitors based on the natural product SFTI-1 / Ashley Buckle, David E. Hoke, Olga Ilyichova, Blake T. Riley, Jonathan M. Harris -- Screening combinatorial peptide libraries in protease inhibitor drug discovery / Paulina Kasperkiewicz, Marcin Poreba, Sanford Burnham Prebys, Marcin Drag and Wioletta Rut -- Chemical probes targeting proteases for imaging and diagnostics in cancer / Pedro Gonçalves and Steven Verhelst -- Cancer diagnostics of protease activity and metastasis / John Beard and Timothy O'Brien -- Roles of pericellular proteases in tumor angiogenesis : therapeutic implications / Janice Kraniak, Raymond R. Mattingly, and Bonnie Sloane
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Cancer -- Treatment -- Technological innovations.
Metastasis -- Treatment -- Technological innovations
Protein-tyrosine kinase.
Tumor suppressor proteins -- Research
Neoplasm Metastasis -- therapy.
Neoplasms -- therapy.
Receptor Protein-Tyrosine Kinases.
Signal Transduction.
Tumor Suppressor Proteins.
Cancer -- Treatment -- Technological innovations.
POLITICAL SCIENCE -- Public Policy -- Social Security.
POLITICAL SCIENCE -- Public Policy -- Social Services & Welfare.
Protein-tyrosine kinase.
Form Electronic book
Author Benson, Roseann, editor.
Janetka, James W., 1968- editor.
LC no. 2018007450
ISBN 1119300207