| Description |
1 online resource (xi, 497 pages) : illustrations (some color) |
| Series |
Cancer Genetics |
|
Cancer genetics.
|
| Contents |
Opening Remarks -- Hardwiring Tumor Progression -- Breaking Away: Epithelial-Mesenchymal Transition -- PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition -- Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells -- Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment -- Merlin/NF2 Tumor Suppressor and Ezrin-Radixin-Moesin (ERM) Proteins in Cancer Development and Progression -- Coming up for Air: Hypoxia and Angiogenesis -- von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization -- RAS Oncogenes and Tumor-Vascular Interface -- Myc and Control of Tumor Neovascularization -- p53 and Angiogenesis -- Ink4a Locus: Beyond Cell Cycle -- Gaining New Ground: Metastasis and Stromal Cell Interactions -- Nm23 as a Metastasis Inhibitor -- HGF/c-MET Signaling in Advanced Cancers -- Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis -- Stromal Cells and Tumor Milieu: PDGF et al. -- TGF-? Signaling Alterations in Neoplastic and Stromal Cells -- Getting Attention: Immune Recognition and Inflammation -- Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers -- Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis -- Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment -- Putting It All Together -- Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface -- Cooperation and Cancer |
| Summary |
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. The commonly held view is that changes in tumor microenvironment are 'soft-wired', that is, epigenetic in nature and often reversible |
| Analysis |
neoplasms |
|
oncologie |
|
oncology |
|
biomedische wetenschappen |
|
biomedicine |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Tumors -- Immunology -- Genetic aspects
|
|
Genomics.
|
|
Cancer -- Genetic aspects.
|
|
Tumors -- Immunological aspects -- Genetic aspects
|
|
Neoplasms -- immunology
|
|
Genomics
|
|
Neoplasms -- etiology
|
|
Neoplasms -- genetics
|
|
MEDICAL -- Oncology.
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
Tumors -- Immunology -- Genetic aspects.
|
|
Genomics.
|
|
Cancer -- Genetic aspects.
|
|
Biomédecine.
|
|
Sciences de la vie.
|
|
Cancer -- Genetic aspects
|
|
Genomics
|
| Form |
Electronic book
|
| Author |
Thomas-Tikhonenko, Andrei
|
| LC no. |
2009934786 |
| ISBN |
9781441907110 |
|
1441907114 |
|
