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Title Proteostasis and disease : from basic mechanisms to clinics / Rosa Barrio, James D. Sutherland, Manuel S. Rodriguez, editors
Published Cham : Springer, [2020]


Description 1 online resource (350 pages)
Series Advances in experimental medicine and biology ; v. 1233
Advances in experimental medicine and biology ; v. 1233.
Contents Intro -- Preface -- Acknowledgments -- Contents -- Part I: Cancer -- Chapter 1: Ubiquitin-Regulated Cell Proliferation and Cancer -- 1.1 Introduction to Cell Cycle Regulation -- 1.1.1 Regulation of CDK-Cyclin Activity by the UPS -- 1.1.2 SCF in Cell Cycle Control -- 1.1.3 SCF in DNA Damage -- 1.1.4 APC/C and the Regulation of Mitosis -- 1.2 Non-proteolytic Protein Ubiquitination in the Control of Cell Cycle Progression -- 1.2.1 Cell Signaling and Non-proteolytic Protein Ubiquitination in G1 -- 1.2.2 Non-proteolytic Protein Ubiquitination During G1/S to G2 Transition Ubiquitin E1 Inhibitors -- Nedd8 E1 Inhibitors -- SUMO E1 Inhibitors -- 2.4.2 E2 Inhibitors -- 2.4.3 E3 Inhibitors -- MDM2 Inhibitors -- IAP Inhibitors -- 2.5 Conclusion -- References -- Chapter 3: The Proteasome System in Health and Disease -- 3.1 Introduction -- 3.2 20S Proteasomes: Structure and Regulation -- 3.2.1 Alternative Composition of the 20S Proteasome -- 3.2.2 Expression and Assembly of the 20S Proteasome -- 3.2.3 Activation of the 20S Proteasome -- 3.2.4 Posttranslational Modifications (PTMs) -- 3.2.5 Localization --3.4 Proteasomes in Diseased States
Summary This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field
Notes Print version record
Subject Proteomics.
Proteins -- Metabolism.
Diseases -- Molecular aspects
Proteasome Endopeptidase Complex
Ubiquitin-Protein Ligases
Proteins -- Metabolism
Genre/Form Llibres electrònics.
Form Electronic book
Author Barrio, Rosa
Rodriguez, Manuel S.
Sutherland, James D
ISBN 9783030382667