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Book Cover
E-book
Author Ciechanover, Aaron J

Title The Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases
Published Singapore : World Scientific Publishing Company, 2002

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Description 1 online resource (240 pages)
Series Recent Advances in Human Biology
Recent advances in human biology.
Contents Preface ; The Ubiquitin System and Some of Its Roles in Cell Cycle Control ; References ; The Ubiquitin System and the N-End Rule Pathway ; Summary ; The Ubiquitin System ; The N-End Rule Pathway ; Physical Association of Ubiquitin Ligases and the 26S Proteasome
Peptide Import and the N-End Rule Pathway The N-End Rule Pathway and Fidelity of Chromosome Segregation ; Concluding Remarks ; References ; Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis ; Abstract
Modular Protein Interaction Domains Regulate Dynamic Cellular Behaviour Protein-Protein Interactions Determine Specificity in Ubiquitin-Mediated Proteolysis ; Cdk Activity and the Control of DNA Replication ; Discovery of SCF Ubiquitin Ligases
Phosphorylation-Dependent Substrate Recognition by SCF Complexes Conservation of SCF Function in the Cell Cycle ; The Cdc4 Phospho-Degron ; Multi-Site Phosphorylation and Ultrasensitivity ; The Sicl-Cdc4 Interaction: Theoretical Considerations ; Discussion ; Prospects ; References
The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis Introduction ; Structural Features of the 26S Proteasome ; Conclusions ; References ; Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105 ; Summary
Summary Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This book tells the story of the ubiquitin system as we currently know it: from the regulation
Bibliography Includes bibliographical references
Notes Print version record
Subject Proteins -- Metabolism.
Proteolytic enzymes.
Ubiquitin.
Enzymes.
Proteins.
Hydrolases.
Cysteine proteinases.
Multienzyme complexes
Ubiquitin
Endopeptidases
Cysteine Proteases
Multiprotein Complexes
Enzymes
Ubiquitins
Enzymes and Coenzymes
Peptide Hydrolases
Proteins
Macromolecular Substances
Hydrolases
Chemicals and Drugs
Amino Acids, Peptides, and Proteins
Cysteine Endopeptidases
Multienzyme Complexes
enzyme.
protein.
Proteins
Multienzyme complexes
Hydrolases
Enzymes
Cysteine proteinases
Proteins -- Metabolism
Proteolytic enzymes
Ubiquitin
Form Electronic book
Author Masucci, Maria G
ISBN 9789812776877
9812776877