Limit search to available items
Book Cover

Title Conjugation and deconjugation of ubiquitin family modifiers / edited by Marcus Groettrup
Published Austin, Tex. : Landes Bioscience ; New York : Springer Science + Business Media, ©2010


Description 1 online resource (xx, 252 pages) : illustrations (some color)
Series Subcellular biochemistry ; v. 54
Sub-cellular biochemistry ; v. 54.
Contents Activation of ubiquitin and ubiquitin-like proteins / Frederick C. Streich Jr. and Arthur L. Haas -- Control of ubiquitin conjugation by CDC48 and its cofactors / Alexander Buchberger -- Regulation of ubiquitin receptors by coupled monoubiquitination / Daniela Hoeller and Ivan Dikic -- Control of cullin-ring ubiquitin ligase activity by Nedd8 / Raymond J. Deshaies, Ethan D. Emberley, and Anjanabha Saha -- Control of deneddylation by the COP9 signalosome / Tilo Schmaler and Wolfgang Dubiel -- Mechanism, specificity, and structure of the deubiquitinases / David Komander -- Ubiquitin conjugation and deconjugation in Nf-kB signaling / Michael Düwel, Kamyar Hadian, and Daniel Krappmann -- Functions of linear ubiquitin chains in the Nf-kB pathway : linear polyubiquitin in Nf-kB signaling / Kazuhiro Iwai -- Assembly of K11-linked ubiquitin chains by the anaphase promoting complex / Michael Rape -- Ubiquitin family members in the regulation of the tumor suppressor p53 / Dimitris P. Xirodimas and Martin Scheffner -- Ubiquitylation in the ERAD pathway / Frederik Eisele, Antje Schäfer, and Dieter H. Wolf -- Pupylation : a signal for proteasomal degradation in mycobacterium tuberculosis / Kristin E. Burns and K. Heran Darwin -- SUMO control / Katharina Maderböck and Andrea Pichler -- The in vivo functions of desumoylating enzymes / Tasneem Bawa-Khalfe and Edward T.H. Yeh -- Regulatory functions of ubiquitin and SUMO in DNA repair pathways / Stefan Jentsch and Stefan Müller -- Sumoylation as a signal for polyubiquitylation and proteasomal degradation / Maria Miteva [and others] -- In vivo functions of isgylation / Klaus-Peter Knobeloch -- Identification and validation of ISG15 target proteins / Larissa A. Durfee and Jon M. Huibregtse -- FAT10 : activated by UBA6 and functioning in protein degradation / Christiane Pelzer and Marcus Groettrup
Summary To cope with the steadily growing body of knowledge and for organizational reasons the articles in this book are focussed on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10 but it should be at least mentioned here that enzymes involved in conjugation and deconjugation of URM1, UFM1, ATG8 and ATG12 have been reported and continue to be investigated
Analysis geneeskunde
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Ubiquitin.
Post-translational modification.
Ubiquitins -- metabolism
Ubiquitin-Protein Ligase Complexes
Sciences de la vie.
Post-translational modification
Form Electronic book
Author Groettrup, Marcus, 1964-
LC no. 2010015269
ISBN 9781441966766