Limit search to available items
Book Cover

Title The proteasome in neurodegeneration / edited by Leonidas Stefanis, Jeffrey N. Keller
Published New York, NY : Springer, ©2006


Description 1 online resource (xv, 306 pages) : illustrations (some color)
Contents Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS) -- Yeast Proteasome Structure and Biogenesis -- Ubiquitin-Proteasome System in the Central Nervous System -- Protein Aggregation, Inclusion Formation and Ups Function -- Protein Aggregation and the UPS: A Two-Way Street -- The Impact of Inclusion Formation on Cell Survival -- Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells -- Oxidative Stress and Ups Function -- The Proteasome: Source and a Target of Oxidative Stress? -- Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction -- Proteasome and Neuronal Cell Death and Survival -- Role of the Ubiquitin Proteasome System During Neuronal Cell Death -- Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition -- Models of Dysfunction of the UPS and the Proteasome -- Pharmacological and Molecular Models of Proteasomal Dysfunction -- The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1 -- The UPS in Neurodegenerative Diseases and Aging -- Parkinson's Disease and Related Disorders -- Ubiquitination by Parkin -- Implications in Parkinson's Disease -- The Ups in Neurodegenerative Diseases and Aging Huntington's Disease -- Frameshift Mutant Ubiquitin in Alzheimer's Disease and Other Neurodegenerative Disorders -- Motor Neuron Disease -- The Paradoxical Role of Proteasomes in Prion Disorders -- Aging and the Proteasome
Summary There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome. Since the discovery of the proteasome some 20 years ago, significant strides have been made in our understanding of proteasome biology and our understanding of the role the proteasome plays in a wide variety of biochemical events. Taken together, these studies have confirmed an important role for the proteasome in the fields of cell biology, oncology, immunology, gerontology, and neuroscience. The focus of this book is to provide an in depth analysis and provocative discussion of what role normal and aberrant proteasome function plays in regulating various aspects of brain homeostasis
Analysis celbiologie
cellular biology
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer e-books
Subject Ubiquitin.
Proteins -- Metabolism.
Nervous system -- Degeneration.
Neurodegenerative Diseases -- metabolism
Proteins -- metabolism
Ubiquitin -- physiology
Proteasome Endopeptidase Complex -- physiology
Ubiquitins -- physiology
MEDICAL -- Nutrition.
Proteasome Endopeptidase Complex -- physiology.
Proteins -- Metabolism.
Ubiquitin -- physiology.
Nervous system -- Degeneration.
Neurodegenerative Diseases -- metabolism.
Sciences de la vie.
Nervous system -- Degeneration
Proteins -- Metabolism
Form Electronic book
Author Stefanis, Leonidas.
Keller, Jeffrey N.
ISBN 9780387285009