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Title Precision molecular pathology of uterine cancer / Michael T. Deavers, Donna M. Coffey, editors
Published Cham : Springer, 2017


Description 1 online resource
Series Molecular pathology library
Molecular pathology library series.
Contents Contents -- Contributors -- Introduction -- 1 Endometrial Carcinoma: Precursor Lesions and Molecular Profiles -- Introduction -- Endometrioid Carcinoma (Type 1) -- Precursor Lesions -- Uterine Serous Carcinoma (Type 2) -- Precursor Lesions -- Molecular Signature -- Molecular Alterations in Endometrioid Carcinoma -- Molecular Alterations in Serous Carcinoma -- Genomic Characterization of USC -- Conclusion -- References -- Endometrial Carcinoma -- 2 Classification of Endometrial Carcinoma -- A Putative Pathogenetic Model for Endometrial Carcinoma
Histopathologic ClassificationEndometrioid Adenocarcinoma -- Mucinous Carcinoma -- Serous Carcinoma -- Clear Cell Carcinoma -- Mixed Carcinoma -- Undifferentiated Carcinoma -- Neuroendocrine Tumors -- Staging of Endometrial Carcinoma -- Prognostic Factors -- Hereditary Endometrial Carcinoma -- References -- 3 Immunohistochemical Markers in Endometrial Carcinoma -- Endometrial Carcinoma Versus ExtramÃơllerian Primaries -- Endometrial Carcinoma Versus Other MÃơllerian Primaries -- Subtyping of Endometrial Carcinoma
Endometrial Carcinoma and Lynch SyndromeAcknowledgements -- References -- 4 Molecular Pathology of Endometrioid Adenocarcinoma -- Introduction -- PI3K/AKT Pathway -- PTEN -- PIK3CA -- PIK3R1 and PIK3R2 -- ARID1A -- KRAS -- CTNNB1 -- TP53 -- Microsatellite Instability -- POLE -- The Cancer Genome Atlas -- Acknowledgement -- References -- 5 The Molecular Pathology of Serous Endometrial Cancer -- Introduction -- Introduction to the Molecular Pathology of SEC -- TP53 Aberrations in SEC -- PI3K Pathway Aberrations in SEC
PI3K Pathway Aberrations as Therapeutic Targets in SECHER2 (ERBB2) Aberrations in SEC -- Î#x97;Î#x95;R2 as a Therapeutic Target in SEC -- FBXW7 Aberrations in SEC -- PPP2R1A Mutations in SEC -- CHD4 Mutations in SEC -- SPOP Mutations in SEC -- TAF1 Mutations in SEC -- Novel Clinical Trial Designs -- Summary and Conclusion -- References -- 6 Uterine Clear Cell Carcinoma -- Introduction -- Histopathologic Features -- Immunophenotypic Features -- Genetic Features -- Biological Function of Immunohistochemical and Genetic Markers -- HNF-1β -- Napsin A
Bax and Bcl-2TP53/p53 -- ARID1A/BAF250a -- PPP2R1A -- PIK3CA -- PTEN -- Precursor Lesion and Oncogenesis -- Similarity and Differences of Molecular Features of Endometrial and Ovarian Clear Cell Carcinoma -- Conclusion and Future Directions -- References -- 7 Mucinous Adenocarcinoma of the Endometrium -- Clinical Features -- Histopathologic Features -- Immunohistochemical Profile -- Differential Diagnosis -- Papillary Mucinous Metaplasia, a Possible Precursor of Mucinous Endometrial Adenocarcinoma -- Pyloric/Gastric Metaplasia of the Endometrium
Summary This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed November 3, 2017)
Subject Uterus -- Cancer.
Precision medicine
Uterine Neoplasms -- pathology
Molecular Diagnostic Techniques
Precision Medicine
Uterine Neoplasms -- genetics
Uterine Neoplasms
Gynaecology & obstetrics.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Personalized medicine.
Uterus -- Cancer.
Form Electronic book
Author Deavers, Michael T., editor.
Coffey, Donna M., editor.
ISBN 9783319579856