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Title V(D)J recombination / edited by Pierre Ferrier
Published New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2009


Description 1 online resource (xvii, 199 pages) : illustrations (some color)
Series Advances in experimental medicine and biology ; v. 650
Advances in experimental medicine and biology ; v. 650.
Contents Early steps of V(D)J rearrangement : insights from biochemical studies of RAG-RSS complexes / Patrick C. Swanson, Sushil Kumar, and Prafulla Raval -- Regulation of RAG transposition / Adam G.W. Matthews and Marjorie A. Oettinger -- Recent insights into the formation of RAG-induced chromosomal translocations / Vicky L. Brandt and David B. Roth -- V(D)J recombination deficiencies / Jean-Pierre de Villartay -- Large-scale chromatin remodeling at the immunoglobulin heavy chain locus : a paradigm for multigene regulation / Daniel J. Bolland, Andrew L. Wood, and Anne E. Corcoran -- Genetic and epigenetic control of V gene rearrangement frequency / Ann J. Feeney -- Dynamic aspects of TCR[alpha] gene recombination : qualitative and quantitative assessments of the TCR[alpha] chain repertoire in man and mouse / Evelyne Jouvin-Marche, Patrizia Fuschiotti, and Patrice Noël Marche -- Germline transcription : a key regulator of accessibility and recombination / Iratxe Abarrategui and Michael S. Krangel
Dynamic regulation of antigen receptor gene assembly / Lance R. Thomas, Robin Milley Cobb, and Eugene M. Oltz -- Molecular genetics at the T-cell receptor b locus : insights into the regulation of V(D)J recombination / Marie Bonnet, Pierre Ferrier, and Salvatore Spicuglia -- Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development / Kristen Johnson, Karen L. Reddy, and Harinder Singh -- Regulation of V(D)J recombinationby E-protein transcription factors / Mary Elizabeth Jones and Yuan Zhuang -- Temporal and spatial regulation of V(D)J recombination : interactions of extrinsic factors with the RAG complex / Yun Liu, Li Zhang, and Stephen Desiderio -- V(D)J recombination : of mice and sharks / Ellen Hsu -- Normal and pathological V(D)J recombination : contribution to the understanding of human lymphoid malignancies / Saïda Dadi [and others]
Summary Features findings concerning the biochemical properties of the V(D)J recombinase (Swanson), it's buried and potentially harmful transposase and translocase activities (Oettinger; Roth), and the importance of NHEJ whose dysfunction causes severe forms of immune deficiencies (de Villartay)
Bibliography Includes bibliographical references and index
Subject Genetic recombination.
DNA-binding proteins.
Recombinant proteins.
Recombination, Genetic
VDJ Recombinases
DNA-Binding Proteins
Recombinant Proteins
SCIENCE -- Life Sciences -- Anatomy & Physiology.
DNA-Binding Proteins.
Recombination, Genetic.
VDJ Recombinases.
Recombinant Proteins.
Genetic recombination.
Sciences de la vie.
Recombinant proteins
DNA-binding proteins
Genetic recombination
Form Electronic book
Author Ferrier, Pierre, 1951-
ISBN 9781441902955
Other Titles VDJ recombination