Title Vascular responses to pathogens / edited by Felicity N.E. Gavins and Karen Y. Stokes

Published London : Academic Press, an imprint of Elsevier, [2016]

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Description 1 online resource : illustrations Contents Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Overview -- Chapter 1 -- Sepsis -- Introduction -- The microcirculation in sepsis -- The endothelium -- Nitric oxide and sepsis -- Arterioles -- Capillaries -- Venules -- Permeability -- Blood cells -- The Inflammatory Response in Sepsis -- Platelets in sepsis -- Thrombosis and coagulation in sepsis -- Models -- Genetics and sepsis -- Treatments for sepsis -- Conclusions -- Acknowledgment -- References -- Chapter 2 -- Neutrophil-Mediated Vascular Host Defense IntroductionBloodstream infections -- Conventional vascular host defense -- Neutrophil extracellular trap mediated vascular immunity -- Immunothrombosis -- NET-mediated tissue damage -- Conclusions -- References -- Chapter 3 -- Platelets as Mediators of the Vascular Response to Infection -- Introduction -- Platelet and hemostasis -- Platelets and the response to infection -- Platelet-bacteria interactions -- Direct binding -- Indirect binding -- Shear stress -- Secreted products -- Platelet activation -- Platelets and sepsis -- Conclusions GBS Surface Adhesins and InvasinsGBS Pili and Other ECM-Binding Proteins -- Signal-transduction mechanisms -- Analysis of the host cell transcriptome in response to bacterial infection -- Meningococcal Infection -- GBS Infection -- Meningococcal Manipulation of the Outer Cell Membrane Lipid Composition -- Summary -- Acknowledgments -- References -- Chapter 5 -- Vascular Responses to Chlamydia pneumoniae Infection -- Introduction -- Direct interaction with vascular cells -- Receptor-Mediated Binding and Uptake C. pneumoniae Uses the Mannose 6-Phosphate Receptor on Endothelial CellsC. pneumoniae Binds to and Activates the LOX-1 Receptor on Endothelial Cells -- The C. pneumoniae Developmental Cycle and Persistent Infection -- Effects on Host Cell Energy Metabolism -- Inflammatory Activation of Vascular Cells and the Role of Toll-Like Receptors -- Foam Cell Formation -- Effects on Host Cell Turnover -- Systemic responses to infection and the impact on the vasculature -- Evidence of the Association of C. pneumoniae Infection and Atherosclerosis in Humans -- Clinical Trials Summary Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease Bibliography Includes bibliographical references and index Notes English Online resource; title from PDF title page (EBSCO, viewed November 5, 2015) Subject Pathogenic microorganisms. Blood-vessels. Cardiovascular system. Vascular Diseases -- immunology Vascular Diseases -- microbiology Infections -- immunology Infections -- metabolism Blood Vessels Cardiovascular System HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Blood-vessels Cardiovascular system Pathogenic microorganisms Genre/Form Electronic book Form Electronic book Author Gavins, Felicity N. E., editor. Stokes, Karen Y., editor. LC no. 2016499414 ISBN 9780128013250 0128013257

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