Title Perspectives On Vasopressin

Published World Scientific 2009

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Description 1 online resource (360) Contents Cover13; -- Contents -- Preface -- Chapter 1. Introduction to Vasopressin (John Laycock) -- 1. Brief Historical Perspective -- 2. General Development, Anatomy and Structure of the Neurohypophysial System -- 3. Synthesis, Storage and Release of Neurohypophysial Hormones -- 4. Vasopressin Assays -- 5. Physiological Actions -- 6. Receptors and Mechanisms of Action -- 7. Circulation and Metabolism -- 8. Control of Release of Vasopressin -- 9. Clinical Aspects of Vasopressin -- 10. Conclusion -- Bibliography -- Chapter 2. Comparative and Evolutionary Aspects of Vasopressin (Jacques Hanoune) -- 1. Introduction -- 2. Evolutionary Aspects of the Vasopressin Family -- 3. Evolutionary Aspects of the Vasopressin Receptor Family -- 4. Evolutionary Aspects of the Aquaporin Family -- 5. Conclusion -- Bibliography -- Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune) -- 1. Developmental Aspects of the Endocrine Hypothalamus -- 2. Biosynthesis -- a) Gene structure -- b) Processing of the mature peptide -- 3. Control of Vasopressin Secretion -- a) Control by extracellular osmolality and volaemia -- b) Additional factors -- 4. Extra-hypothalamic Expression of Vasopressin -- a) Adrenal medulla -- b) Testis -- c) Blood vessels and heart -- d) Other organs -- 5. Peripheral Degradation and Metabolic Clearance -- Bibliography -- Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action (Jacques Hanoune) -- 1. Introduction: A Short Historical Survey of Vasopressin Receptors -- 2. Pharmacological Characterization of the Vasopressin Receptors -- 3. Biochemical Characterization of the Vasopressin Receptors -- 4. Tissue Expression -- a) V1a receptor -- b) V1b (V3) receptor -- c) V2 receptor -- 5. Vasopressin Receptors and G Proteins: An Overview -- 6. Structure of the Vasopressin Receptors -- a) General features -- b) Modelling of vasopressin receptors -- 7. Structural Basis of the Receptor-Ligand Interaction -- a) Binding of agonists -- b) Binding of antagonists -- 8. Domains Responsible for G Protein-Coupling Selectivity -- 9. Dimerization of Receptors -- 10. Signalling Pathways -- a) The heterotrimeric G protein -- b) The cyclic AMP pathway -- c) The calcium/phosphatidyl inositol pathway -- d) The V2 receptor pathway -- e) The V1a receptor pathway -- f) The V1b receptor pathway -- g) The proteomic approach -- 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression -- 12. Downregulation of Vasopressin Receptors: Desensitization and Internalization -- 13. Are There Other Vasopressin Receptors? -- Bibliography -- Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune) -- 1. Introduction -- 2. Radio-labelled Ligands -- 3. Pharmacology of the Vasopressin V1a Receptor -- 4. Pharmacology of the Vasopressin V1b Receptor -- 5. Pharmacology of the Vasopressin V2 Receptor -- 6. Mixed Vasopressin V1a/V2 Receptor Antagonists -- 7. Inter-species and Inter-organ Variability -- 8. Conclusion -- Bibliography -- Chapter 6. Vasopressin and Its Renal Effects (John Laycock) -- 1. Introduction -- 2. The Kidneys -- 3. The Renal Actions of Vasopressin -- a) Glomerular filtration and renal blood flow -- b) Vasopressin and the proximal tubule -- c) Vasopressin and the loop of Henle -- d) Vasopressin an Summary Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotran Notes English Subject Vasopressin. Pituitary hormones. Oligopeptides. Neuropeptides. Nerve tissue proteins. Peptide hormones. Proteins. Hormones. Pituitary Hormones, Posterior Oligopeptides Neuropeptides Pituitary Hormones Peptides Nerve Tissue Proteins Amino Acids, Peptides, and Proteins Peptide Hormones Proteins Chemicals and Drugs Hormones Vasopressins Hormones, Hormone Substitutes, and Hormone Antagonists protein. hormone. Neurology. Clinical Medicine. Proteins Pituitary hormones Peptide hormones Oligopeptides Neuropeptides Nerve tissue proteins Hormones Vasopressin Form Electronic book ISBN 1282759809 9781282759800 9781848162952 1848162952 1848162944 9781848162945

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