| Description |
1 online resource (248 pages) |
| Series |
Molecular Biology Intelligence Unit |
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Molecular biology intelligence unit.
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| Contents |
COVER; Title Page. Molecular Mechanisms of Muscular Dystrophies; Copyright ©2006; Table of Contents; Editor and Contributors; Foreword; Acknowledgments; CHAPTER 1. Structure and Function of the Dystrophin-Glycoprotein Complex; CHAPTER 2. The Structure and Function of Dystrophin; CHAPTER 3. Utrophin in the Therapy of Duchenne Muscular Dystrophy; CHAPTER 4. Syntrophin: A Molecular Adaptor Conferring a Signaling Role to the Dystrophin-Associated Protein Complex; CHAPTER 5. Molecular and Functional Diversity of Dystrobrevin-Containing Complexes |
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CHAPTER 6. Commonalities and Differences in Muscular Dystrophies: Mechanisms and Molecules Involved in Merosin-Deficient Congenital Muscular DystrophyCHAPTER 7. Glycosylation and Muscular Dystrophy; CHAPTER 8. Overview of the Limb-Girdle Muscular Dystrophies and Dysferlinopathy; CHAPTER 9. Caveolin-3 and Limb-Girdle Muscular Dystrophy; CHAPTER 10. The Sarcoglycans; CHAPTER 11. Sarcomeric Proteins in LGMD; CHAPTER 12. Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection |
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CHAPTER 13. Distinct Mechanisms Downstream of the Repeat Expansion Are Implicated in the Molecular Basis of Myotonic Dystrophy Type 1CHAPTER 14. Spinal Muscular Atrophy; CHAPTER 15. The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy; CHAPTER 16. Cell Adhesion and Signalling in the Muscular Dystrophies; CHAPTER 17. Gene Therapies for Muscular Dystrophies; CHAPTER 18. Cell Therapies for Muscular Dystrophy; INDEX; A-F; G-N; P-Z; BACK COVER |
| Summary |
The first detailed study of the clinical features, hereditary nature and pathology of muscular dystrophy is attributed to Edward Meryon, an English physician, who published his findings in 1852. Yet it was more than 130 years later that the responsible gene for the commonest form of dystrophy, Duchenne muscular dystrophy, was identified and characterised. Subsequently the genes for many other forms of dystrophy have been identified, and it is estimated that there are now approaching 40 such disorders, though some of these are very rare. However once the gene for Duchenne dystrophy had been ide |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Print version record |
| Subject |
Muscular dystrophy -- Molecular aspects
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Dystrophin -- genetics
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Muscular Dystrophies -- genetics
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Dystrophin-Associated Proteins -- genetics
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MEDICAL -- Orthopedics.
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HEALTH & FITNESS -- Diseases -- Musculoskeletal.
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MEDICAL -- Rheumatology.
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| Form |
Electronic book
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| ISBN |
9781587063947 |
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1587063948 |
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