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Title Adenosine receptors in neurodegenerative diseases / edited by David Blum, Luísa V. Lopes
Published London, United Kingdom : Academic Press is an imprint of Elsevier, 2017


Description 1 online resource
Contents Front Cover; Adenosine Receptors in Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Foreword and History of Adenosine in the Central Nervous System; References; Acknowledgments; I. Physiology; 1 Adenosine Receptor Biology in the Central Nervous System; Sources of Adenosine in the CNS; Receptor Subtypes and Their CNS Distribution; A1 Adenosine Receptors; A2A Adenosine Receptors; A2B Adenosine Receptors; A3 Adenosine Receptors; Crosstalk With Other Receptors; Adenosine and CNS Diseases; Recent Clinical Trials; A1 Adenosine Receptors
A2A Adenosine ReceptorsA2B Adenosine Receptors; A3 Adenosine Receptors; References; 2 Adenosine Signaling Throughout Development; Introduction; Effects of Adenosine Signaling and Its Dysfunction in CNS; Effects of Adenosine in Oligodendrocytes Development; Effects of Adenosine on Cardiovascular System During Embryogenesis; Postnatal Effects of Adenosine on Cardiovascular System; Postnatal Effect of Adenosine on Respiratory System; Use of Methylxanthines in Premature Babies; Postnatal Effects of Adenosine on the Genitourinary System; Postnatal Effect of Adenosine on the Enteric System
Postnatal Effect of Adenosine on Other SystemsConclusion; References; 3 Influence of Adenosine on Synaptic Excitability; Introduction; Molecular & Physiological Mechanisms; Influence on Neurotransmitter Availability and Basal Synaptic Transmission; Adenosine Tunes the Responses of Postsynaptic Glutamate and GABA Receptors; Astrocyte-Derived Adenosine Controls Basal Synaptic Transmission and the Available Range for Plasticity Control; Metamodulation by Adenosine: Impact on Synaptic Plasticity; Adenosine Shapes Synapses for Plasticity; Implications for Epilepsy; Pathophysiological Mechanisms
Adenosine Receptor-Dependent EffectsAdenosine Receptor-Independent Effects; Disruption of Adenosine Homeostasis in Epilepsy; Comorbidities of Epilepsy; Therapeutic Implications; Conclusions and Outlook; Acknowledgments; References; 4 Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction; Introduction; Neuromuscular Junction; Structural Organization of the Neuromuscular Junction; Neuromuscular Transmission; Coexistence of Transmitters and Neuromodulators; Adenosine as a Neuromodulator at the Neuromuscular Junction
Pathways: Synthesis and Degradation of Adenosine at the Neuromuscular JunctionAdenosine Receptors; Nerve Terminals; Schwann Cells; Adenosine Receptors and Their Interactions With Other Receptors at the Neuromuscular Junction; Crosstalk Between A1 and A2A Receptors; Crosstalk Between Adenosine Receptors and Acetylcholine Receptors; Adenosine Receptors and BDNF Actions; Adenosine Signaling in Ageing and Disease; Conclusions; References; 5 Gene Regulation of Adenosine A2A Receptors in the Central Nervous System; General Introduction; A2AR Promoter and Gene Structure; Epigenetics of ADORA2A
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (ScienceDirect, viewed March 22, 2017)
Subject Adenosine -- Receptors
Nervous system -- Degeneration -- Molecular aspects
Receptors, Purinergic P1
Neurodegenerative Diseases
Receptor, Adenosine A2A
SCIENCE -- Life Sciences -- Biochemistry.
Adenosine -- Receptors
Nervous system -- Degeneration -- Molecular aspects
Genre/Form Computer network resources
Form Electronic book
Author Blum, David, editor
Lopes, Luísa V., editor
ISBN 9780128037454