| Description |
1 online resource (xv, 511 pages) : illustrations (some color) |
| Series |
Advances in experimental medicine and biology ; v. 570 |
|
Advances in experimental medicine and biology ; v. 570.
|
| Contents |
The problem of genome instability. The multiplicity of mutations in human cancers / Ranga N. Venkatesan and Lawrence A. Loeb. Monitoring chromosome rearrangements / Michael R. Speicher -- DNA repair and mutagenesis. Nucleotide excision repair and its connection with cancer and ageing / Jaan-Olle Andressoo, Jan H.J. Hoeijmakers and Harm de Waard. DNA mismatch repair and colon cancer / Giancarlo Marra and Josef Jiricny. Base excision repair / Lisiane B. Meira, Nicholas E. Burgis and Leona D. Samson. Genomic instability in cancer development / Penny A. Jeggo. Translesion synthesis and error-prone polymerases / Catherine M. Green and Alan R. Lehmann -- Cell cycle progression and chromosome aberration. The INK4A/ARF network-cell cycle checkpoint or emergency brake? / Ana Gutierrez del Arroyo and Gordon Peters. DNA replication and genomic instability / Wenge Zhu, Tarek Abbas and Anindya Dutta. The dream of every chromosome: equal segregation for a healthy life of the host / Tomohiro Matsumoto and Mitsuhiro Yanagida. Telomere structural dynamics in genome integrity control and carcinogenesis / Roger A. Greenberg and K. Lenhard Rudolph. Gene amplification mechanisms / Michelle Debatisse and Bernard Malfoy. DNA methylation and cancer-associated genetic instability / Melanie Ehrlich. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer / Wilma L. Lingle, Kara Lukaswiewicz and Jeffrey L. Salisbury -- Genome integrity checkpoints. Mammalian DNA damage response pathway / Zhenkun Lou and Junjie Chen. ATM and cellular response to DNA damage / Martin F. Lavin [and others] Mitotic checkpoint, aneuploidy and cancer / Tim J. Yen and Gary D. Kao |
| Summary |
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called 'proto-oncogenes' and 'tumour suppressor genes', whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that "cancer" is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as 'genome instability', so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
OhioLINK electronic book center |
|
SpringerLink |
| Subject |
Cancer -- Genetic aspects.
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Genomics.
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Mutation (Biology)
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DNA repair.
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Neoplasms -- genetics
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Neoplasms -- etiology
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Genomic Instability
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Mutation
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DNA Repair
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Genomics
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Biomédecine.
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Sciences de la vie.
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Mutation (Biology)
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DNA repair
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Cancer -- Genetic aspects
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Genomics
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| Form |
Electronic book
|
| Author |
Nigg, Erich A
|
| LC no. |
2007275129 |
| ISBN |
1402037643 |
|
9781402037641 |
|
6610459541 |
|
9786610459544 |
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