| Description |
1 online resource (xix, 172 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 677 |
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Advances in experimental medicine and biology ; v. 677.
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| Contents |
Energetics of peptide and protein binding to lipid membranes / William C. Wimley -- Membrane association and pore formation by alpha-helical peptides / Burkhard Bechinger -- Role of membrane lipids for the activity of pore forming peptides and proteins / Gustavo Fuertes [and others] -- Cholesterol-dependent cytolysins / Robert J.C. Gilbert -- Laetiporus sulphureus lectin and aerolysin protein family / Jose Miguel Manchero . [and others] -- Interfacial interactions of pore-forming colicins / Helen Ridley, Christopher L. Johnson and Jeremy H. Lakey -- Permeabilization of the outer mitochondrial membrane by BCL-2 proteins / Ana J. Garcia-Suez [and others] -- Molecular mechanism of sphingomyelin : specific membrane binding and pore formation by actinoporins / Biserka Bakra and Gregor Anderluh |
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Hemolysin E (hlye, clya, shea) and related toxins / Stuart Hunt, Jeffrey Green and Peter J. Artymiuk -- Pore formation by cry toxins / Mario Soberin [and others] -- Role of heparan sulfates and glycosphingolipids in the pore formation of basic polypeptides of cobra cardiotoxin / Wen-guey Wu [and others] -- Amyloid peptide pores and the beta sheet conformation / Bruce L. Kagan and Jyothi Thundimadathil |
| Summary |
There are currently only two structures of pores available, of I -toxin from Staphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels i |
| Analysis |
geneeskunde |
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medicine |
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biomedische wetenschappen |
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biomedicine |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Membrane proteins.
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Membrane lipids.
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Carrier proteins.
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Cells -- Permeability.
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Membrane Proteins -- physiology
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Carrier Proteins
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Peptides -- physiology
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Pore Forming Cytotoxic Proteins -- physiology
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Cell Membrane Permeability
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Membrane Lipids -- physiology
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Membrane Proteins
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Membrane Lipids
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SCIENCE -- Life Sciences -- Biochemistry.
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Biomédecine.
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Sciences de la vie.
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Cells -- Permeability
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Carrier proteins
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Membrane lipids
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Membrane proteins
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| Form |
Electronic book
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| Author |
Anderluh, Gregor, 1969-
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Lakey, Jeremy, 1958-
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| ISBN |
9781441963277 |
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1441963278 |
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9781441963260 |
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144196326X |
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1283074443 |
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9781283074445 |
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