| Description |
1 online resource (xxiv, 324 pages) : illustrations (chiefly color) |
| Series |
Tumor dormancy and cellular quiescence and senescence ; volume 1 |
|
Tumor dormancy and cellular quiescence and senescence ; v. 1.
|
| Contents |
Tumor dormancy. Dormancy, quiescence, and cellular senescence / M.A. Hayat -- Is tumor dormancy clinically relevant? / Dieter Hölzel, Renate Eckel, Rebecca Emeny, Jutta Engel -- Microenvironmental influence on breast cancer dormancy and metastasis / George R. Nahas, Jacqueline M. Park, Pranela Rameshwar -- Determination of breast cancer dormancy: analysis of circulating free DNA using SNP 6.0 arrays / Jacqui Shaw, Kevin Blighe, Karen Page, David Guttery, R. Charles Coombes -- Clonogenicity of cultured prostate cancer cells is controlled by dormancy: significance and comparison with cell culture models of breast cancer cell dormancy / Thierry Tchénio -- Dormancy and metastasis of melanoma cells to lymph nodes, lung and liver / Vincent L. Morris, Dean B. Percy, Michael M. Lizardo -- Late recurrence is a sign of melanoma dormancy: need of life-long follow-up of melanoma patients / Uwe Wollina -- Quiescence. Hematopoietic stem cell quiescence and long term maintenance: role of SCL/TAL1 / Shanti Rojas-Sutterlin, Trang Hoang -- Regulation of muscle stem cell quiescent and undifferentiated state: roles of Hesr1 and Hesr3 genes / Masahiko Yamaguchi, So-ichiro Fukada -- The kinase MIRK/DYRK1B mediates a reversible quiescent state in a subset of ovarian, pancreatic and colon cancers / Eileen A. Friedman -- Cellular senescence. Stress-induced senescence: molecular pathways / Peter J. Hornsby -- Accumulation of reactive oxygen species and induction of premature senescence: role of DDB2 / Nilotpal Roy, Pradip Raychaudhuri -- p21 mediates senescence by a mechanism involving accumulation of reactive oxygen species / Ionica Masgras, Salvador Macip -- Role of micrornas and ZEB1 downmodulation in oxidative stress-induced apoptosis and senescence / Alessandra Magenta, Maurizio C. Capogrossi -- Hypoxic response in senescent brain is impaired: possible contribution to neurodegeneration / Tamer Rabie -- Enhancing reprogramming to pluripotency by controlling senescence / Ana Banito, Jesús Gil |
|
Histone deacetylase inhibitor induces replicative senescence of mesenchymal stem cells / Seunghee Lee, Ji-Won Jung, Kyung-Sun Kang -- Senescence arrest of endopolyploid cells renders senescence into one mechanism for positive tumorigenesis / Kirsten H. Walen -- The two faces of senescence-associated epigenetic alterations: tumor suppressors and oncogenic drivers / Anabelle Decottignies -- Chemotherapy- and radiation-induced accelerated senescence: implications for treatment response, tumor progression and cancer survivorship / Molly L. Bristol, Lynne W. Elmore -- Suppression of cellular senescence in glioblastoma: role of Src homology domain-containing phosphatase 2 / Lisa-Marie Sturla, Pascal Zinn, Ekkehard Kasper -- Chemotherapy of malignant pleural mesothelioma induces both senescence and apoptosis / Emanuela Felley-Bosco, Rolf A. Stahel -- Microrna as a modulator of cell proliferation and senescence: role in lung cancer cells / Sayuri Fukui, Masaki Sekiguchi, Kenichi Miyata, Hiroaki Ohdaira, Kenichi Yoshida -- Role of senescence induction in cancer therapy / Hiroshi Kondoh, Takumi Mikawa, Matilde E. LLeonart -- Cellular senescence limits the extent of fibrosis following liver damage / Valery Krizhanovsky -- Formation of secretory senescent cells in prostate tumors: the role of androgen receptor activity and cell cycle regulation / Zuzana Pernicová, Petr Vaňhara, Karel Souček |
| Summary |
With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors--both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Online resource; title from resource home page (SpringerLink, viewed October 21, 2015) |
| Subject |
Tumors.
|
|
Aging.
|
|
Neoplasms
|
|
Aging
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
MEDICAL -- Oncology.
|
|
Aging
|
|
Tumors
|
| Form |
Electronic book
|
| Author |
Hayat, M. A., 1940- editor.
|
| ISBN |
9789400759589 |
|
9400759584 |
|
