| Description |
1 online resource |
| Contents |
Intro -- Foreword -- Preface -- Contents -- About the Editors -- Discovering the Role of Mannose-Binding Lectin (MBL) in Innate Immunity: The Early History -- Introduction -- Early Studies on Defective Opsonisation -- A Question of Nomenclature -- A Decade of Biochemical Studies -- Microbiological Studies in the 1980s -- Determination of the Underlying Cause of the Opsonic Deficiency -- Some Concluding Thoughts -- References -- Mannose-Binding Lectin in Human Health and Disease -- Introduction -- MBL Structure -- Various Functions of MBL -- Binding of MBL with Ligands and Pathogens |
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Physiological Role of MBL -- MBL-Associated Serine Proteases -- Serum MBL Levels -- MBL Genetics and Deficiency -- Organization of the Human MBL2 Gene -- Deficiency -- MBL Associated with Diseases -- MBL and Infection -- Neonatal Sepsis -- Autoimmune Diseases -- MBL Replacement Therapy -- Conclusions and Perspectives -- References -- Activities of MASPs, The Complement Proteases Associated with Collectins and Ficolins -- Brief History -- The Role of MASPs in Lectin Pathway Activation -- Role of the MASPs in the Alternative Pathway Activation |
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Cross-Talk Between the Lectin Pathway and Coagulation -- Endothelial Cell Activation by MASP-1 -- Regulation of MASPs -- Conclusion and Perspectives -- References -- Structures of the MASP Proteases and Comparison with Complement C1r and C1s -- Common Protease Modular Structure and Mode of Interaction with Defence Collagens -- Central CUB1-EGF Interactions in LP and CP Proteases Assembly: A Marked Similarity -- Similar Interaction Properties Mediate Protease Association with Defence Collagens -- Opposite Binding Orientations for CUB1 and CUB2 Modules with Collagen: A Structural View |
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How Details of CUB-Collagen Interactions Explain the Differences in Orientation -- CUB1-EGF-CUB2 Homodimer (LP) Versus Heterodimer (CP) Interactions: Common Features and Differences -- How CCP1 and CCP2 Modulate LP and CP Catalytic Activities -- CCP1-CCP2 as Elongated Arms or Handles -- CCP1-CCP2 Include a C4 Binding Exosite in MASP-2 and C1s -- CCP Modules Potentially Restricting Spontaneous Activation: A C1r Exception -- Structural Similarities in the C-Terminal Trypsin-Like SP Domain -- Structural Differences Shaping Protease Specificity, an Opportunity to Design Specific Inhibitors |
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Structural Uncertainties Beyond Common Principles in the LP and CP Activation Mechanism -- LP and CP Protease Enzymatic Activities Out of the Complement System -- General Comments and Conclusion -- References -- Biological Activities of SP-A and SP-D Against Extracellular and Intracellular Pathogens -- Introduction -- Protective Effects of SP-A and SP-D Against Viral Pathogens -- Influenza A Virus -- Human Immunodeficiency Virus-1 (HIV-1) -- Herpes Simplex Viruses (HSV) -- Respiratory Syncytial Virus (RSV) -- Human Papillomavirus (HPV) -- SARS Coronavirus (SARS CoV) -- Other Viruses |
| Summary |
The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed April 12, 2021) |
| Subject |
Collectins.
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Natural immunity.
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Immunity, Innate
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Collectins
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Natural immunity
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Kishore, Uday, editor.
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Madan, Taruna, editor
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Sim, Robert B., editor.
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| ISBN |
9783030670481 |
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3030670481 |
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