| Description |
1 online resource (215 p.) |
| Series |
Frontiers in Neurotherapeutics Ser |
|
Frontiers in Neurotherapeutics Ser
|
| Contents |
Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Table of Contents -- Preface -- About the Editors -- Contributors -- Section I: Introduction and Basic Principles -- Chapter 1 Introduction -- Endogenous Opioids Lead the Way -- Endogenous Benzodiazepines -- Implications -- References -- Chapter 2 Benzodiazepines and Related Substances: Chemistry -- Introduction -- Structural Features of Benzodiazepines -- Discovery and Synthesis of 1,4-Benzodiazepines -- Classification of Benzodiazepines according to Elimination Half-Life -- Structure-Activity Relationships (SAR) |
|
Benzodiazepines "Designer Drugs" -- Imidazo-Benzodiazepines -- Naturally Occurring Benzodiazepines -- Z-Drugs -- Conclusions -- References -- Chapter 3 Central Benzodiazepine Receptors: Structure and Function -- Benzodiazepine Receptor-Structure -- Benzodiazepine Modulation of the GABA[sub(A)] Receptor -- Benzodiazepine agonism -- Benzodiazepine antagonism -- Reverse agonism -- Receptor Subtype Composition May Alter Benzodiazepine Effects -- Summary -- References -- Chapter 4 Benzodiazepines and Related Substances: Therapeutic Uses and Problems -- Introduction |
|
Types of Ligand Binding at the GABA[sub(A)] Receptor (GABA[sub(A)] R) -- Interactions of Endogenous Substances (Endozepines, EDZs) with the GABA[sub(A)] Receptor -- Distribution in other Tissues -- Modulation of EDZ Release by Neurotransmitters, Neuropeptides, and Drugs -- Pharmacology and Therapeutic Uses of Benzodiazepines -- Overview -- Use in Management of Anxiety -- Induction of Anesthesia -- Skeletal Muscle Relaxation -- Anticonvulsant Activity -- Alcohol Withdrawal -- Selection of Benzodiazepine and Tapering Regimen -- Types of Tapering Regimens |
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Adverse Events and other Problems Associated with BZDs -- Benzodiazepines and Z-drugs as Risk Factors for Dementia -- BZDs and Opioids -- Prescribing Patterns for BZDs and Opioids -- Monitoring Opioid and BZD Use by Health Practitioners and the General Population -- Psychomotor and Behavioral Effects of BZDs and Opioids -- Opioid Overdose Deaths (OODs) -- Substances related to BZDs: Z-drugs -- Mechanisms of Action for Z-drugs and Clinical Indications -- Clinical Uses and Indications for Z-drugs -- Insomnia -- Zolpidem -- Zaleplon -- Eszopiclone -- Side Effects of Z-drugs |
|
Adverse Events Associated with all Z-drugs -- Benzodiazepine Receptor Antagonist: Flumazenil -- Conclusions -- References -- Chapter 5 Peripheral Benzodiazepine Receptors -- Introduction -- Discovery of Peripheral Binding Sites for Benzodiazepines -- Molecular Structure -- Localization and Functions -- Role of PBR during Benzodiazepine Treatment and Withdrawal -- References -- Section II: Naturally Occurring Benzodiazepines -- Chapter 6 The Search for Endogenous Benzodiazepines in Humans -- Introduction -- Endozepines: Fact, Fiction, or Wishful Thinking? -- Future Directions |
| Notes |
Description based upon print version of record |
|
Still Looking for the Endogenous PAM |
| Form |
Electronic book
|
| Author |
Amantea, Diana
|
| ISBN |
9781000421255 |
|
1000421252 |
|
