| Description |
1 online resource (279 pages) |
| Series |
Frontiers in Structural Biology Ser. ; v. 1 |
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Frontiers in Structural Biology Ser
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| Contents |
880-01 Intro; CONTENTS; PREFACE; List of Contributors; Regulatory Roles for Hsp70 in Cancer Incidence and Tumor Progression; Taka Eguchi1, Benjamin J. Lang1, Ayesha Murshid1, Thomas Prince2, Jianlin Gong3 and Stuart K Calderwood1,*; 1. INTRODUCTION; 2. HSP70 PROTEINS IN THE CYTOPLASM AND NUCLEUS; 3. MUTATION AND OVEREXPRESSION OF HSP72 IN CANCER; 4. HSP72 AND THE HALLMARKS OF CANCER; 4A. HSP72 Suppresses Apoptotic Cell Death in Cancer; 4B. HSP72 and Senescence; 4C. HSP72 in Tumor Initiation and Metastasis; 4D. HsSP72 in Sustained Angiogenesis |
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880-01/(S Definition and Prediction of the Sequence and Basic Structure of TPR MotifsThree Dimensional Structure; Curvature and Shape of the TPR Domain; Examples of TPR Protein Structures; Ligand Binding; Folding and Stability of TPR Proteins; Oligomerization, Stability and Biological Functions; Novel TPR Protein Design; SEQUENCE, FUNCTION, AND BASIC STRUCTURE OF HSP90 PROTEINS: HSP90 ALPHA AND BETA; Introduction; Hsp90 Isoforms; Sequence and Basic Structure of Hsp90 Proteins: Hsp90 α and β; Difference in Structure of Hsp90 α−and β−isoforms; Conformational Changes in Hsp90 |
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5. DRUGGING HSP70 IN CANCER: ISOFORMS AND DRUGGABLE DOMAINS5A. Targeting the HSP70 Substrate-Binding Domain (SBD); 5B. Targeting the HSP70 Nucleotide-Binding Domain; 5C. Perturbation of HSP70-Protein Interactions; CONCLUSIONS; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Use of Coarse-Grained and All-Atom Molecular Dynamics to Study Hsp70 and Hsp40 Chaperone Action; Ewa I. Gołaś1,2,œ, Magdalena A. Mozolewska1,2,œ, Paweł Krupa1,2, Cezary Czaplewski1, Harold A. Scheraga2 and Adam Liwo1,*; INTRODUCTION; METHODS; RESULTS; Mechanism of Chaperone Cycle |
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Modeling Iron-sulfur Cluster BiogenesisModeling the Structure of Isu1 from Yeast; Modeling the Structure of the Binary Isu1-Jac1 Complex and Assessing the Stability of its Interactions; Preliminary Molecular-modeling Study of the Structure of the Isu1-Jac1-Ssq1 Ternary Complex; CONCLUSIONS AND OUTLOOK; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Quaternary Structure of Chaperones from the Hsp70 System Determined by Small Angle X-Ray Scattering (SAXS) and Analytical Ultra-centrifugation; Júlio C. Borges1 and Carlos H.I. Ramos2,*; INTRODUCTION |
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Protein Folding and Molecular ChaperonesSmall Angle X-ray Scattering (SAXS); Analytical Ultracentrifugation; The Hsp70-folding System; Human Mitochondrial GrpE, Conformational Modification upon Hsp70 Binding; Eukaryotic Hsp40s Types I and II, on the Position of the J Domain; FINAL REMARKS; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGMENTS; REFERENCES; Structural Characteristics of the TPR Protein-Hsp90 Interaction: A New Target in Biotechnology; Ana Cauerhff1,* and Mario D. Galigniana1,2; INTRODUCTION; TPR PROTEIN CHARACTERISTICS |
| Notes |
Sequence of Conformational Changes Induced by ATP Binding to Hsp90 |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Molecular chaperones.
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Molecular chaperones
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| Form |
Electronic book
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| ISBN |
1681086158 |
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9781681086156 |
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