| Description |
1 online resource |
| Series |
Handbook of clinical neurology ; volume 146 |
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Handbook of clinical neurology ; volume 146.
|
| Contents |
Front Cover -- Cerebrospinal Fluid in Neurologic Disorders -- Copyright -- Available titles -- Foreword -- Preface -- Contributors -- Contents -- Section I: General aspects -- Chapter 1: The use of cerebrospinal fluid in biomarker studies -- Introduction -- Definition of biomarkers and type of biomarkers -- Physiology of CSF -- Biomarker subtypes -- Proteins -- Metabolites -- Cell-free DNA -- Messenger RNA/micro RNA -- Exosomes -- Sample collection and biobanking: preanalytic variation -- Patient-related factors -- Age and sex |
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Genetic backgroundCircadian rhythm -- Coffee, chocolate, smoking, and alcohol consumption -- Preanalytic procedures -- Lumbar puncture -- Risk factors and recommendations in performing an LP -- Type of tube -- Evaporation -- Centrifugation speed and temperature -- Quality assessment of collection procedures -- Analytic aspects in CSF biomarker studies: assay development and validation -- Technical analysis: optimizing immunoassay validation and development of novel biomarkers -- Quality assessment of analytic procedures -- Matrix reference material |
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Clinical study design in CSF biomarker studiesDiscussion: how to increase the number of novel biomarkers? -- Concluding remarks -- References -- Chapter 2: The cerebrospinal fluid and barriers -- anatomic and physiologic considerations -- Introduction -- Physiology of CSF: what is CSF good for, where does it come from, how is it circulating, where does it go? -- Biologic function -- Sites of production -- Circulation -- Absorption -- Transfer mechanisms -- Barriers of the CNS compartment: what are the differences between BBB and BCB? -- The blood-brain barrier |
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The blood-CSF barrierAnatomy of CSF spaces: which brain areas are reflected by CSF analysis? -- CSF constituents: which factors influence their concentration and what is their implication for CSF analysis? -- Circadian changes -- Site of sampling (lumbar vs. ventricular CSF) -- Volume of CSF sampled -- Physical activity and head movement -- Clearance via specific transporters -- Surgical intervention -- Concluding remarks -- References -- Chapter 3: More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue |
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The concept of volume transmissionThe functional influence of CSF on brain cells -- Adult neurogenesis -- CSF-contacting neurons -- The functional contribution of CSF in pathologic CNS conditions -- Traumatic brain injury (TBI) -- Anti-NMDAR encephalopathy -- Brain aging and dementia -- Summary -- Abbreviations -- References -- Chapter 4: Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models -- Introduction -- CSF and brain interstitial fluid |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed November 1, 2017) |
| Subject |
Cerebrospinal fluid.
|
|
Nervous system -- Diseases.
|
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Cerebrospinal Fluid
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Nervous System Diseases
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Nervous system -- Diseases
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Cerebrospinal fluid
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| Form |
Electronic book
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| Author |
Deisenhammer, Florian.
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|
Teunissen, Charlotte E.
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Tumani, Hayrettin
|
| ISBN |
9780128043240 |
|
0128043245 |
|
