| Description |
1 online resource (194 pages) |
| Series |
Advances in Experimental Medicine and Biology ; v. 1246 |
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Advances in experimental medicine and biology ; v. 1246.
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| Contents |
Intro -- Preface -- Contents -- Contributors -- 1 An Introduction to Phagocytosis -- Introduction to Phagocytosis -- The Cell Biology of Phagocytosis -- Phagocytosis Dissected -- The Importance of Phagocytosis -- Evolution and Phagocytosis -- Introduction to the Chapters in This Book -- 2 A Brief History of Phagocytosis -- Introduction -- Purpose of Chapter -- Let's Start at the Very Beginning -- The Eureka Moment of Metchnikoff -- Inside the Phagocyte -- Phagosomal pH -- Ca2+ Ions and Phagocytosis -- Conclusion -- 3 The Role of Membrane Surface Charge in Phagocytosis -- Introduction |
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Lipids That Contribute to Phagocytosis and Phagosome Maturation -- Phospholipid Dynamics and Inner Leaflet Charge During Phagocytosis and Phagosome Maturation -- Role of Electrostatic Interactions in Protein Localization During Phagocytosis and Phagosome Maturation -- Relevance of Inner Leaflet Surface Charge to Phagocytes and Immunity -- Concluding Remarks -- 4 Receptor Models of Phagocytosis: The Effect of Target Shape -- Introduction -- Why Modelling? -- Receptor Models of Phagocytosis -- The Basic Receptor Model -- Phagocytosis Versus Other Types of Endocytosis -- The Effect of Target Shape |
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Known Experimental Results -- Modelling Shape Dependence -- Model Extensions and the Future -- Summary -- 5 Decision Making in Phagocytosis -- Introduction -- Uptake, Processing, and Release of Long Particles -- Uptake of a Long Particle -- Phagosome Processing -- Release of a Particle -- Myosin-II Does Not Accumulate on the Incipient Phagosome -- Conversion of a Tubular Phagosome into a Bleb -- Simultaneous Uptake and Release of Particles -- Struggle for a Bacterium -- Discussion -- 6 Membrane Tension and the Role of Ezrin During Phagocytosis -- Introduction |
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Apparent Expansion of Cell Surface Area During Phagocytosis -- Exocytotic Addition to the Plasma Membrane -- Cell Surface "Wrinkles" -- Membrane Tension and Cell Shape Changes -- Wrinkles and Membrane Tension -- Molecular Maintenance of Membrane Tension -- Ezrin -- Ezrin and Membrane Tension -- Ezrin and Phagocytosis -- Regulation Membrane Tension by Ezrin During Phagocytosis -- Actin Push and the Brownian Ratchet -- Conclusion and Synthesis -- 7 Molecular Mechanisms of Calcium Signaling During Phagocytosis -- Abbreviations -- Introduction -- Overview of Ca2+ Signaling -- Phagocytic Ca2+ Signals |
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Ca2+-Permeable Channels Involved in Phagocytic Ca2+ Signals -- ORAI Channels, STIM Proteins and Junctate -- TRPC Channels -- TRPC3 -- TRPC4/5 -- TRPC6 -- TRPM Channels -- TRPM2 -- TRPM8 -- TRPML Channels -- TRPV Channels -- TRPV1 and TRPV2 -- TRPV4 -- P2X Channels -- P2X7 -- P2X4 -- Conclusions and Future Directions -- 8 Calpain Activation by Ca2+ and Its Role in Phagocytosis -- Introduction -- Ca2+ in Phagocytosis and Cell Shape Change -- Calpain Activation in Shape Change -- Calpain in Phagocytosis -- Structure of Calpain 1 and 2 -- Physiological Activation of Calpain by Ca2+ in Cells |
| Summary |
Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably "primitive") cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the "natural" immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches |
| Notes |
Conclusions |
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Includes index |
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Print version record |
| Subject |
Phagocytosis.
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Phagocytosis
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Medical research.
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Medical microbiology & virology.
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Cellular biology (cytology)
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Biochemistry.
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Immunology.
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Science -- Life Sciences -- Biology -- Molecular Biology.
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Medical -- Microbiology.
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Science -- Life Sciences -- Biochemistry.
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Medical -- Immunology.
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Phagocytosis
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| Form |
Electronic book
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| Author |
Hallett, Maurice B. (Maurice Bartlett), 1952-
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| ISBN |
9783030404062 |
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3030404064 |
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