| Description |
1 online resource (xii, 328 pages) : illustrations (some color) |
| Series |
Computational Biology, 1568-2684 ; 19 |
|
Computational biology ; 19.
|
| Contents |
Part I: Emergence of Standard Algorithms. What's Behind Blast / Gene Myers -- Forty Years of Model-Based Phylogeography / David Bryant and Jamie Kydd -- How to Infer Ancestral Genome Features by Parsimony: Dynamic Programming over an Evolutionary Tree / Miklós Csűrös -- Duplication, Rearrangement and Reconciliation: A Follow-Up 13 Years Later / Cedric Chauve [and others] -- The Genesis of the DCJ Formula / Anne Bergeron and Jens Stoye -- Part II: New Lights on Current Paradigms. Large-Scale Multiple Sequence Alignment and Phylogeny Estimation / Tandy Warnow -- Rearrangements in Phylogenetic Inference: Compare, Model, or Encode? / Bernard M.E. Moret, Yu Lin and Jijun Tang -- Status of Research on Insertion and Deletion Variations in the Human Population / Liqing Zhang, Mingming Liu and Layne T. Watson -- A Retrospective on Genomic Preprocessing for Comparative Genomics / Binhai Zhu -- The Emperor Has No Caps! A Comparison of DCJ and Algebraic Distances / Joao Meidanis and Sophia Yancopoulos -- Part III: Promising Directions. Fractionation, Rearrangement, Consolidation, Reconstruction / David Sankoff and Chunfang Zheng -- Error Detection and Correction of Gene Trees / Manuel Lafond, Krister M. Swenson and Nadia El-Mabrouk -- The Potential of Family-Free Genome Comparison / Marília D.V. Braga [and others] -- Genetic History of Populations: Limits to Inference / Daniel E. Platt [and others] |
| Summary |
This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. Topics and features: Discusses the development of the BLAST algorithm, model-based phylogeography techniques, and the double cut and join (DCJ) distance formula. Reviews the reconstruction of evolutionary features of ancestral genomes in a known phylogeny, and presents integrative models of evolution Introduces algorithms to estimate alignment and phylogeny on ultra-large datasets, and an approach for using likelihood methods with rearrangement models. Examines the impact of insertion and deletion variants in human biology, evolution and health Surveys novel and recent research on genomic distance and family-free genome comparison. Describes consolidation methods for reconstruction of ancestral gene orders, and error detection in gene tree construction Investigates the genetic events recoverable from simulations of human population histories. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Online resource; title from PDF title page (SpringerLink, viewed September 24, 2013) |
| Subject |
Comparative genomics.
|
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Computational biology.
|
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Molecular evolution.
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Genomics.
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Genomics
|
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Computational Biology
|
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Evolution, Molecular
|
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SCIENCE -- Life Sciences -- Biochemistry.
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Genomics
|
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Comparative genomics
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Computational biology
|
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Molecular evolution
|
| Form |
Electronic book
|
| Author |
Chauve, Cedric, editor
|
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El-Mabrouk, Nadia, editor
|
|
Tannier, Eric, editor
|
| ISBN |
9781447152989 |
|
1447152980 |
|
1447152972 |
|
9781447152972 |
|
