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Title Theranostics, Gallium-68, and other radionuclides : a pathway to personalized diagnosis and treatment / Richard P. Baum, Frank Rösch, editors
Published Berlin ; New York : Springer, ©2013

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Description 1 online resource : illustrations (some color)
Series Recent results in cancer research, 0080-0015 ; v. 194
Recent results in cancer research ; v. 194.
Contents Part 1. Generators -- ⁶⁸sGe/⁶⁸sGa Generators: Past, Present, and Future / F. Rösch -- Overview and Perspectives on Automation Strategies in ⁶⁸sGa Radiopharmaceutical Preparations / Stefano Boschi, Claudio Malizia and Filippo Lodi -- Post-Processing via Cation Exchange Cartridges: Versatile Options / F. Rösch -- ⁶⁸sGa Generator Integrated System: Elution-Purification-Concentration Integration / Van So Le -- Purification and Labeling Strategies for ⁶⁸sGa from ⁶⁸sGe/⁶⁸sGa Generator Eluate / Dirk Mueller, Ingo Klette and Richard P. Baum -- 67Ga and ⁶⁸sGa Purification Studies: Preliminary Results / R.F. Costa, M.F. Barboza and J.A. Osso Jr
Part 2. Radiochemistry and Radiopharmacy -- The Diversity of ⁶⁸sGa-Based Imaging Agents / Irina Velikyan -- Nanoparticles and Phage Display Selected Peptides for Imaging and Therapy of Cancer / Cathy S. Cutler, Nripen Chanda, Ravi Shukla, Nebiat Sisay and Melchor Cantorias, et al. -- Click-Cyclized ⁶⁸sGa-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model System / Molly E. Martin, M. Sue O'Dorisio, Whitney M. Leverich, Kyle C. Kloepping and Susan A. Walsh, et al. -- Early Experience with ⁶⁸sGa-DOTATATE Preparation / Maung Maung Saw -- ⁶⁸sGa-Radiopharmaceuticals for PET Imaging of Infection and Inflammation / Vijay Kumar and Dilip K. Boddeti -- ⁶⁸sGa-Labeled Bombesin Analogs for Receptor-Mediated Imaging / Raunak Varshney, Puja P. Hazari, P. Fernandez, J. Schulz and M. Allard, et al. -- A Novel ⁶⁸sGa-Labeled Pteroic Acid-Based PET Tracer for Tumor Imaging via the Folate Receptor / Berit Kühle, Cristina Müller and Tobias L. Ross -- Measurement of Protein Synthesis: In Vitro Comparison of ⁶⁸sGa-DOTA-Puromycin, [³sH]Tyrosine, and 2-Fluoro-[³sH]tyrosine / Sebastian Eigner, Denis R. Beckford Vera, Marco Fellner, Natalia S. Loktionova and Markus Piel, et al. -- Hypoxia Imaging Agents Labeled with Positron Emitters / Lathika Hoigebazar and Jae Min Jeong -- ¹⁷⁷sLu/⁹⁰sYIntermediate-Affinity Monoclonal Antibodies Targeting EGFR and HER2/c-neu: Preparation and Preclinical Evaluation / Denis R. Beckford Vera, Sebastian Eigner, Katerina Eigner Henke, Rene Leyva Montaña and Frantisek Melichar, et al
Part 3. Molecular Imaging Using Ga-68 labeled Tracers -- Divergent Role of ⁶⁸sGa-Labeled Somatostatin Analogs in the Workup of Patients with NETs: AIIMS Experience / Niraj Naswa and C.S. Bal -- Differential Uptake of ⁶⁸sGa-DOTATOC and ⁶⁸sGa-DOTATATE in PET/CT of Gastroenteropancreatic Neuroendocrine Tumors / Thorsten D. Poeppel, Ina Binse, Stephan Petersenn, Harald Lahner and Matthias Schott, et al. -- High Uptake of ⁶⁸sGa-DOTATOC in Spleen as Compared to Splenosis: Measurement by PET/CT / Harshad R. Kulkarni, Vikas Prasad, Daniel Kaemmerer, Merten Hommann and Richard P. Baum -- Rare Metastases Detected by ⁶⁸sGa-Somatostatin Receptor PET/CT in Patients with Neuroendocrine Tumors / Cecilia Carreras, Harshad R. Kulkarni and Richard P. Baum -- Comparison of Different Positron Emission Tomography Tracers in Patients with Recurrent Medullary Thyroid Carcinoma: Our Experience and a Review of the Literature / Giorgio Treglia, Paola Castaldi, Maria Felicia Villani, Germano Perotti and Angelina Filice, et al. -- PET Lung Ventilation/Perfusion Imaging Using ⁶⁸sGa Aerosol (Galligas) and ⁶⁸sGa-Labeled Macroaggregated Albumin / S.J. Ament, S. Maus, H. Reber, H.G. Buchholz and N. Bausbacher, et al. -- Combined PET/MR Imaging Using ⁶⁸sGa-DOTATOC for Radiotherapy Treatment Planning in Meningioma Patients / Daniela Thorwarth, Arndt-Christian Müller, Christina Pfannenberg and Thomas Beyer
Part 4. Targeted Radiotherapy (Peptide Receptor Radionuclide Therapy) and Dosimetry -- A Rare Case of a Large Spinal Meningioma with Mediastinal Extension and Malignant Behavior Classified Histologically as Benign / S. Dahdal, R.H. Andres, E. Hewer, J.C. Reubi and B. Klaeser, et al. -- Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors in Germany: First Results of a Multi-institutional Cancer Registry / Dieter Hörsch, Samer Ezziddin, Alexander Haug, Klaus Friedrich Gratz and Simone Dunkelmann, et al. -- Polish Experience in Peptide Receptor Radionuclide Therapy / Jolanta Kunikowska, Leszek Królicki, Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk and Dariusz Pawlak, et al. -- PRRT as Neoadjuvant Treatment in NET / Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk and Monika Tomaszuk -- Intraoperative Somatostatin Receptor Detection After Peptide Receptor Radionuclide Therapy with ¹⁷⁷sLu- and ⁹⁰sY-DOTATOC (Tandem PRRNT) in a Patient with a Metastatic Neuroendocrine Tumor / Mila Todorović-Tirnanić, Daniel Kaemmerer, Vikas Prasad, Merten Hommann and Richard P. Baum -- Personalized Image-Based Radiation Dosimetry for Routine Clinical Use in Peptide Receptor Radionuclide Therapy: Pretherapy Experience / Anna Celler, Joshua Grimes, Sergey Shcherbinin, Hanna Piwowarska-Bilska and Bozena Birkenfeld -- The Bad Berka Dose Protocol: Comparative Results of Dosimetry in Peptide Receptor Radionuclide Therapy Using ¹⁷⁷sLu-DOTATATE, ¹⁷⁷sLu-DOTANOC, and ¹⁷⁷sLu-DOTATOC / Christiane Schuchardt, Harshad R. Kulkarni, Vikas Prasad, Carolin Zachert and Dirk Müller, et al. -- 4D SPECT/CT Acquisition for 3D Dose Calculation and Dose Planning in ¹⁷⁷sLu-Peptide Receptor Radionuclide Therapy: Applications for Clinical Routine / Kalevi Kairemo and Aki Kangasmäki -- Peptide Receptor Radionuclide Therapy with ¹⁷⁷sLu Labeled Somatostatin Analogs DOTATATE and DOTATOC: Contrasting Renal Dosimetry in the Same Patient / Harshad R. Kulkarni, Christiane Schuchardt and Richard P. Baum -- Is There a Correlation Between Peptide Receptor Radionuclide Therapy-Associated Hematological Toxicity and Spleen Dose? / Harshad R. Kulkarni, Vikas Prasad, Christiane Schuchardt and Richard P. Baum -- Old and New Peptide Receptor Targets in Cancer: Future Directions / Jean Claude Reubi
Part 1. Generators -- ⁶⁸Ge/⁶⁸Ga Generators: Past, Present, and Future / F. Rösch -- Overview and Perspectives on Automation Strategies in ⁶⁸Ga Radiopharmaceutical Preparations / Stefano Boschi, Claudio Malizia and Filippo Lodi -- Post-Processing via Cation Exchange Cartridges: Versatile Options / F. Rösch -- ⁶⁸Ga Generator Integrated System: Elution-Purification-Concentration Integration / Van So Le -- Purification and Labeling Strategies for ⁶⁸Ga from ⁶⁸Ge/⁶⁸Ga Generator Eluate / Dirk Mueller, Ingo Klette and Richard P. Baum -- 67Ga and ⁶⁸Ga Purification Studies: Preliminary Results / R.F. Costa, M.F. Barboza and J.A. Osso Jr
Part 2. Radiochemistry and Radiopharmacy -- The Diversity of ⁶⁸Ga-Based Imaging Agents / Irina Velikyan -- Nanoparticles and Phage Display Selected Peptides for Imaging and Therapy of Cancer / Cathy S. Cutler, Nripen Chanda, Ravi Shukla, Nebiat Sisay and Melchor Cantorias, et al. -- Click-Cyclized ⁶⁸Ga-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model System / Molly E. Martin, M. Sue O'Dorisio, Whitney M. Leverich, Kyle C. Kloepping and Susan A. Walsh, et al. -- Early Experience with ⁶⁸Ga-DOTATATE Preparation / Maung Maung Saw -- ⁶⁸Ga-Radiopharmaceuticals for PET Imaging of Infection and Inflammation / Vijay Kumar and Dilip K. Boddeti -- ⁶⁸Ga-Labeled Bombesin Analogs for Receptor-Mediated Imaging / Raunak Varshney, Puja P. Hazari, P. Fernandez, J. Schulz and M. Allard, et al. -- A Novel ⁶⁸Ga-Labeled Pteroic Acid-Based PET Tracer for Tumor Imaging via the Folate Receptor / Berit Kühle, Cristina Müller and Tobias L. Ross -- Measurement of Protein Synthesis: In Vitro Comparison of ⁶⁸Ga-DOTA-Puromycin, [³H]Tyrosine, and 2-Fluoro-[³H]tyrosine / Sebastian Eigner, Denis R. Beckford Vera, Marco Fellner, Natalia S. Loktionova and Markus Piel, et al. -- Hypoxia Imaging Agents Labeled with Positron Emitters / Lathika Hoigebazar and Jae Min Jeong -- ¹⁷⁷Lu/⁹⁰YIntermediate-Affinity Monoclonal Antibodies Targeting EGFR and HER2/c-neu: Preparation and Preclinical Evaluation / Denis R. Beckford Vera, Sebastian Eigner, Katerina Eigner Henke, Rene Leyva Montaña and Frantisek Melichar, et al
Part 3. Molecular Imaging Using Ga-68 labeled Tracers -- Divergent Role of ⁶⁸Ga-Labeled Somatostatin Analogs in the Workup of Patients with NETs: AIIMS Experience / Niraj Naswa and C.S. Bal -- Differential Uptake of ⁶⁸Ga-DOTATOC and ⁶⁸Ga-DOTATATE in PET/CT of Gastroenteropancreatic Neuroendocrine Tumors / Thorsten D. Poeppel, Ina Binse, Stephan Petersenn, Harald Lahner and Matthias Schott, et al. -- High Uptake of ⁶⁸Ga-DOTATOC in Spleen as Compared to Splenosis: Measurement by PET/CT / Harshad R. Kulkarni, Vikas Prasad, Daniel Kaemmerer, Merten Hommann and Richard P. Baum -- Rare Metastases Detected by ⁶⁸Ga-Somatostatin Receptor PET/CT in Patients with Neuroendocrine Tumors / Cecilia Carreras, Harshad R. Kulkarni and Richard P. Baum -- Comparison of Different Positron Emission Tomography Tracers in Patients with Recurrent Medullary Thyroid Carcinoma: Our Experience and a Review of the Literature / Giorgio Treglia, Paola Castaldi, Maria Felicia Villani, Germano Perotti and Angelina Filice, et al. -- PET Lung Ventilation/Perfusion Imaging Using ⁶⁸Ga Aerosol (Galligas) and ⁶⁸Ga-Labeled Macroaggregated Albumin / S.J. Ament, S. Maus, H. Reber, H.G. Buchholz and N. Bausbacher, et al. -- Combined PET/MR Imaging Using ⁶⁸Ga-DOTATOC for Radiotherapy Treatment Planning in Meningioma Patients / Daniela Thorwarth, Arndt-Christian Müller, Christina Pfannenberg and Thomas Beyer
Part 4. Targeted Radiotherapy (Peptide Receptor Radionuclide Therapy) and Dosimetry -- A Rare Case of a Large Spinal Meningioma with Mediastinal Extension and Malignant Behavior Classified Histologically as Benign / S. Dahdal, R.H. Andres, E. Hewer, J.C. Reubi and B. Klaeser, et al. -- Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors in Germany: First Results of a Multi-institutional Cancer Registry / Dieter Hörsch, Samer Ezziddin, Alexander Haug, Klaus Friedrich Gratz and Simone Dunkelmann, et al. -- Polish Experience in Peptide Receptor Radionuclide Therapy / Jolanta Kunikowska, Leszek Królicki, Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk and Dariusz Pawlak, et al. -- PRRT as Neoadjuvant Treatment in NET / Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk and Monika Tomaszuk -- Intraoperative Somatostatin Receptor Detection After Peptide Receptor Radionuclide Therapy with ¹⁷⁷Lu- and ⁹⁰Y-DOTATOC (Tandem PRRNT) in a Patient with a Metastatic Neuroendocrine Tumor / Mila Todorović-Tirnanić, Daniel Kaemmerer, Vikas Prasad, Merten Hommann and Richard P. Baum -- Personalized Image-Based Radiation Dosimetry for Routine Clinical Use in Peptide Receptor Radionuclide Therapy: Pretherapy Experience / Anna Celler, Joshua Grimes, Sergey Shcherbinin, Hanna Piwowarska-Bilska and Bozena Birkenfeld -- The Bad Berka Dose Protocol: Comparative Results of Dosimetry in Peptide Receptor Radionuclide Therapy Using ¹⁷⁷Lu-DOTATATE, ¹⁷⁷Lu-DOTANOC, and ¹⁷⁷Lu-DOTATOC / Christiane Schuchardt, Harshad R. Kulkarni, Vikas Prasad, Carolin Zachert and Dirk Müller, et al. -- 4D SPECT/CT Acquisition for 3D Dose Calculation and Dose Planning in ¹⁷⁷Lu-Peptide Receptor Radionuclide Therapy: Applications for Clinical Routine / Kalevi Kairemo and Aki Kangasmäki -- Peptide Receptor Radionuclide Therapy with ¹⁷⁷Lu Labeled Somatostatin Analogs DOTATATE and DOTATOC: Contrasting Renal Dosimetry in the Same Patient / Harshad R. Kulkarni, Christiane Schuchardt and Richard P. Baum -- Is There a Correlation Between Peptide Receptor Radionuclide Therapy-Associated Hematological Toxicity and Spleen Dose? / Harshad R. Kulkarni, Vikas Prasad, Christiane Schuchardt and Richard P. Baum -- Old and New Peptide Receptor Targets in Cancer: Future Directions / Jean Claude Reubi
Summary This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy
Analysis Medicine
Radiology, Medical
Nuclear medicine
Radiotherapy
Oncology
Medicine & Public Health
Neuroradiology
Molecular Medicine
Bibliography Includes bibliographical references
Notes English
Subject Radioisotopes -- Therapeutic use.
Radioisotopes in medical diagnosis.
Radioisotope scanning.
Radiopharmaceuticals.
Gallium Radioisotopes
Radionuclide Imaging
Neoplasms -- diagnosis
Neoplasms -- therapy
Positron-Emission Tomography and Computed Tomography
Radiopharmaceuticals
PSYCHOLOGY -- Psychotherapy -- General.
Médecine.
Radiopharmaceuticals
Radioisotope scanning
Radioisotopes in medical diagnosis
Radioisotopes -- Therapeutic use
Genre/Form Online-Publikation.
Form Electronic book
Author Baum, Richard P., 1954-
Rösch, Frank.
ISBN 9783642279942
3642279945
3642279937
9783642279935
1283612623
9781283612623
9786613925077
6613925071