Title Glycoscience and microbial adhesion / edited by Thisbe K. Lindhorst, Stefan Oscarson

Published Berlin ; London : Springer, 2009

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Description 1 online resource Series Topics in current chemistry ; 288 Topics in current chemistry ; 288. Contents Carbohydrate receptors of bacterial adhesins: Implications and reflections / K. Ohlsen [and others] -- Ins and outs of microbial adhesion / M. Virji -- Architectures of multivalent glycomimetics for probing carbohydrate-lectin interactions / M. Lahmann -- Structure, function, and assembly of type 1 fimbriae / S. Knight and J. Bouckaert -- The multiple carbohydrate binding specificities of helicobacter pylori / S. Teneberg -- Bitter sweetness of complexity / A. Horst and C. Wagener -- Staphylococcus epidermidis biofilms: Functional molecules, relation to virulence, and vaccine potential / D. Mack [and others] Summary Bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, "Bitter sweetness of complexity," the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its "guest," as well as the biological consequences resulting from this mutual interplay Bibliography Includes bibliographical references and index Notes English Print version record Subject Glycoconjugates. Microorganisms -- Adhesion. Glycosylation. Bacterial Adhesion -- physiology Glycoconjugates Adhesins, Bacterial Glycocalyx -- metabolism Glycosylation Glycoconjugates. Microorganisms -- Adhesion. Science des matériaux. Chimie. Glycosylation Glycoconjugates Microorganisms -- Adhesion Adhäsion Glykokonjugate Kohlenhydrate Mikroorganismus Zelladhäsion Genre/Form Aufsatzsammlung. Form Electronic book Author Lindhorst, Thisbe K Oscarson, Stefan ISBN 9783642013041 364201304X 3642013031 9783642013034 1280382775 9781280382772 9786613560681 6613560685

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