| Description |
1 online resource (xii, 269 pages) : illustrations (some color), maps (some color) |
| Contents |
880-01 1. Introduction to population diversity and genetic testing / Michael D. Caldwell [and others] -- 2. Genotyping techniques / Cristi R. King and Sharon Marsh -- 3. Pharmacokinetics: absorption, distribution, metabolism, excretion overview chapter / Terrence Blaschke -- 4 . Overview, adverse drug reactions / Matthew R. Nelson -- 5. ParhmGKB, a centralized resource for pharmacogenomic knowledge and discovery / Li Gong and Teri E. Klein -- 6. DrugBank / David S. Wishart -- 7. Ethical considerations for pharmacogenomics: privacy and confidentiality / Sandra Sao-Jin Lee -- 8. Informed consent in pharmacogenomic research and treatment / Mark A. Rothstein -- 9. Legal trends driving the clinical translation of pharmacogenomics / Barbara J. Evans -- 10. Oncologic drugs / Uchenna O. Njiaju and M. Eileen Dolan-- 11. Pharmacogenetics and pharmacogenomics of cardiovascular disease / Daniel Kurnick and C. Michael Stein -- 12. Statin-induced muscle toxicity / Russel A. Wilke [and others] -- 13. Genomics of the drug-induced long-QT syndrome / Dan M. Roden -- 14. Pharmacogenetics of diabetes / Mark C.H. de Groot and Olaf H. Klongel -- 15. Pharmacogenetics, therapeutic area, respiratory / Kelan Tantisira and Scott Weiss -- 16. Pharmacogenetcs associated with therapy for acid-related discorders / Takahisa Furuta -- 17. Pharmacogenetics of rheumatology: focus on rheumatoid arthiritis / Rober M. Plenge [and others] -- 18. Pharmacogenetics of obstetric therapeutics / David Hass and Jamie Renbarger-- 19. Pharmacogenomics of psychiatric drugs / David Mrazek -- 20. Pain and anesthesia / Konrad Meissner and Evan D. Kharasch -- 21. HIV and antiretroviral therapy / Amalia Telenti -- 22. Applications of pharmacogenetics and pharmacogenetics in pediatrics: what makes children different? / Jennifer A. Lowry and Steven Leeder -- 23. Fetal and neonatal pharmacogenomics / Yair Blumenfeld |
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880-01/(S Meglitinides and Polymorphisms -- Sulfonylureas and Biguanides and Insulin Receptor Substrate Polymorphisms -- Sulfonylureas and Biguanides and KCNJ11 Polymorphisms -- Sulfonylureas and Biguanides and Transcription Factor-7-Like 2 Polymorphisms -- Thiazolidiones, Acarbose, and PPARγ Polymorphisms -- Thiazolidiones, Acarbose, and Adiponectin Polymorphisms -- Incretin Mimetics/DPP-4 Inhibitors -- Candidate Genes in the Causal Pathway -- CONCLUSION -- REFERENCES -- 15: Pharmacogenetics -- Therapeutic Area -- Respiratory -- INTRODUCTION: THE BURDEN OF RESPIRATORY DISEASE -- Pharmacogenetic Categories -- Pulmonary Pharmacogenetic Phenotypes -- Summary -- THE PHARMACOGENETICS OF ASTHMA -- Asthma Pharmacogenetic Phenotypes -- The Pharmacogenetics of Asthma -- Overview of Studies to Date -- The β2-Adrenergic Receptor Pathway -- The Leukotriene Antagonist Pathway -- The Corticosteroid Pathway -- Asthma Pharmacogenetics -- The Future -- THE PHARMACOGENETICS OF COPD -- Potential COPD Pharmacogenetic Phenotypes -- The Pharmacogenetics of Smoking Cessation -- Pharmacokinetic Paradigm -- Pharmacodynamic Paradigm -- The Future of COPD Pharmacogenetics -- CONCLUSION -- DISCUSSION QUESTIONS -- REFERENCES -- 16: Pharmacogenomics Associated with Therapy for Acid-Related Disorders -- EFFECTS OF CYP2C19 POLYMORPHISM ON THE PKs AND PDs OF PPIs -- Genetic Differences in the PPI-Metabolizing Enzyme, CYP2C19 -- Effect of CYP2C19 Polymorphism on the PKs of PPIs -- Effect of CYP2C19 Polymorphism on Gastric Acid Inhibition with PPIs -- Intragastric pH on Frequent PPI Dosing -- Influence of CYP2C19 Genotype Status on the PKs and PDs of Different PPIs -- EFFECT OF CYP2C19 POLYMORPHISM ON GERD TREATMENT BY PPI -- EFFECT OF CYP2C19 POLYMORPHISM ON PEPTIC ULCER HEALING WITH A PPI -- EFFECTS OF CYP2C19 POLYMORPHISM ON PPI-BASED ERADICATION THERAPY OF H. pylori |
| Summary |
"This book is intended to introduce the field of phamacogenetics and pharmacogenomics to health care professionals. It brings together the latest informaiton about how human genetics impacts drug response phenotypes. It is written to enable the reader to undestand the current knowledge and challenges to the field"--Provided by publisher |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Pharmacogenetics.
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Pharmacogenetics
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Pharmacological Phenomena -- genetics
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MEDICAL -- Pharmacology.
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Pharmacogenetics
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Pharmakogenetik
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| Form |
Electronic book
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| Author |
Altman, Russ.
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Flockhart, David A
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Goldstein, David B
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| ISBN |
9781139233545 |
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1139233548 |
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9781139230544 |
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1139230549 |
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1280568976 |
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9781280568978 |
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9781139051194 |
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1139051199 |
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9781139232005 |
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1139232002 |
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