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Book Cover
E-book
Author Chow, Shein-Chung, 1955-

Title Adaptive design methods in clinical trials / Shein-Chung Chow, Mark Chang
Edition 2nd ed
Published Boca Raton, FL : CRC Press, [2012]
©2012
Online access available from:
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Description 1 online resource (xvi, 358 pages) : illustrations
Series Chapman & Hall/CRC biostatistics series
Chapman & Hall/CRC biostatistics series.
Contents Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance
Summary With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology. New to the Second Edition Along with revisions throughout the text
Notes "A Chapman & Hall book."
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Clinical Trials as Topic -- methods.
Research Design.
Biometry -- methods.
Models, Statistical.
Adaptive sampling (Statistics)
Clinical trials -- Statistical methods.
Clinical trials.
Experimental design.
Adaptive sampling (Statistics)
Clinical trials -- Statistical methods.
Clinical trials.
Experimental design.
MEDICAL -- Laboratory Medicine.
Form Electronic book
Author Chang, Mark.
ISBN 1439839883
9781439839881