Description |
1 online resource (viii, 247 pages) : illustrations (some color) |
Series |
Advances in experimental medicine and biology, 0065-2598 ; v. 1255 |
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Advances in experimental medicine and biology ; v. 1255
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Contents |
Values of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells |
Summary |
With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients |
Subject |
DNA -- Methylation
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Sequence alignment (Bioinformatics)
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Pathology, Cellular.
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Cytology.
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Methylation.
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Nucleotide sequence.
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NA Methylation
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Sequence Alignment
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Cell Biology
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Methylation
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Base Sequence
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Cytology
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Molecular biology.
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Oncology.
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Medical research.
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Science -- Life Sciences -- Anatomy & Physiology.
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Medical -- Oncology.
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Science -- Life Sciences -- Biology -- Molecular Biology.
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Nucleotide sequence
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Methylation
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Cytology
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DNA -- Methylation
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Pathology, Cellular
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Sequence alignment (Bioinformatics)
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Form |
Electronic book
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Author |
Yu, Buwei
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Zhang, Jiaqiang
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Zeng, Yiming
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Li, Li
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Wang, Xiangdong (Professor of clinical bioinformatics)
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ISBN |
9789811544941 |
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9811544948 |
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