Title Single-cell sequencing and methylation : methods and clinical applications / Buwei Yu, Jiaqiang Zhang, Yiming Zeng, Li Li, Xiangdong Wang, editors

Published Singapore : Springer, 2020

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Description 1 online resource (viii, 247 pages) : illustrations (some color) Series Advances in experimental medicine and biology, 0065-2598 ; v. 1255 Advances in experimental medicine and biology ; v. 1255 Contents Values of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells Summary With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients Subject DNA -- Methylation Sequence alignment (Bioinformatics) Pathology, Cellular. Cytology. Methylation. Nucleotide sequence. NA Methylation Sequence Alignment Cell Biology Methylation Base Sequence Cytology Molecular biology. Oncology. Medical research. Science -- Life Sciences -- Anatomy & Physiology. Medical -- Oncology. Science -- Life Sciences -- Biology -- Molecular Biology. Nucleotide sequence Methylation Cytology DNA -- Methylation Pathology, Cellular Sequence alignment (Bioinformatics) Form Electronic book Author Yu, Buwei Zhang, Jiaqiang Zeng, Yiming Li, Li Wang, Xiangdong (Professor of clinical bioinformatics) ISBN 9789811544941 9811544948

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