| Description |
1 online resource (139 pages) |
| Contents |
Front Cover; Advances in Genetics; Copyright; Contents; Contributors; Chapter One: A Kernel of Truth: Statistical Advances in Polygenic Variance Component Models for Complex Human Pedigrees; 1. Introduction; 2. VCs Models; 2.1. Standard polygenic model; 2.2. Eigensimplification of the MVN likelihood; 3. Expected Likelihood Ratio Test Statistics; 3.1. Heritability; 3.2. Association in the presence of residual heritability; 4. Power and Asymptotic Relative Efficiency; 4.1. Power; 4.2. Asymptotic relative efficiency; 4.2.1. Heritability; 4.2.2. Association |
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5. Utility of Eigensimplification for the Polygenic Model5.1. Analytic eigenvalues for pedigree-derived GRKs; 5.2. Power functions for heritability and association; 5.3. Asymptotic relative efficiency; 5.4. Inadequacy of the asymptotic LRT distribution for VC testing; 6. Analysis of Empirical GRKs; 7. Discussion; Acknowledgments; References; Chapter Two: Fungal Cell Wall Organization and Biosynthesis; 1. Introduction and Overview: General Organization of the Fungal Cell Wall; 2. Methods Used in Studying the Cell Wall; 3. The Specific Components Found in Fungal Cell Walls |
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3.1. Chitin and chitosan3.2. Ý-1,3-Glucans; 3.3. Mixed Ý-1,3-/Ý-1,4-glucans; 3.4. Ý-1,6-Glucans; 3.5. Ü-1,3-Glucans; 3.6. Melanins; 3.7. Cell wall glycoproteins; 3.7.1. GPI anchoring; 3.7.2. N-linked and O-linked mannans and galactomannans; 3.8. Functions ascribed to individual cell wall proteins; 3.8.1. Cell wall biogenesis; 3.8.2. The Gas1p/GEL1/Phr1p family of Ý-1,3-glucanases; 3.8.3. The Crh/Utr family of Ý-1,3-glucanases; 3.8.4. The Bgl2p/Scw4p/Scw10p/Scw11p family of Ý-1,3-glucanases; 3.8.5. The DFG5/DCW1 family of Ü-1,6-mannanases; 3.8.6. Chitinases; 3.8.7. Structural proteins |
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3.8.8. Adhesins3.8.9. Receptors for signal transduction pathways: CWI; 3.8.10. Other cell wall proteins; 4. Well-Characterized Fungal Cell Walls; 4.1. The S. cerevisiae cell wall; 4.2. The C. albicans cell wall; 4.3. The A. fumigatus cell wall; 4.4. The S. pombe cell wall; 4.5. The N. crassa cell wall; 4.6. The C. neoformans cell wall; 5. Conclusions: Variability in Cell Wall Components and Redundancy in Cell Wall Biosynthesis; Acknowledgments; References; Chapter Three: Polycomb Group Response Elements in Drosophila and Vertebrates; 1. Introduction; 2. PREs in Drosophila |
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2.1. PRE maintenance assays2.2. Mini-white silencing; 2.3. Effect of flanking regulatory DNA on PRE activity; 2.4. PREs can facilitate transcriptional activation or repression; 2.5. DNA binding proteins and sequence motifs associated with PREs; 2.5.1. Pho and Phol; 2.5.2. Sp/KLF proteins; 2.5.3. GAGAG sites; 2.5.4. GTGT sequence; 2.5.5. Dsp1; 2.5.6. Grh; 2.5.7. Zeste binding sites; 2.6. Are all PREs alike?; 3. Characteristics of PcG Target Genes in Drosophila; 3.1. Many PcG targets have multiple PREs; 3.1.1. eve; 3.1.2. en/inv; 3.1.3. Psc/Su(z)2; 3.2. Homing and PcG target genes |
| Summary |
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future |
| Notes |
Print version record |
| Subject |
Molecular genetics.
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Plant genetics.
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Cancer -- Genetic aspects.
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SCIENCE -- Life Sciences -- Evolution.
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Cancer -- Genetic aspects
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Molecular genetics
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Plant genetics
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| Form |
Electronic book
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| Author |
Dunlap, Jay C
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Goodwin, Stephen F
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| ISBN |
9780124078024 |
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0124078028 |
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