| Description |
1 online resource (xix, 278 pages) : illustrations (some color) |
| Contents |
Foreword; Foreword; Preface; Contents; Contributors; About the Editor; Part I Stem Cells: Science/Concepts and Database; Promises of Stem Cell Research and Therapeutics; Introduction; Stem Cell Backgrounder; History of Stem Cells from the Scratch; Timeline of Stem Cell Research; Stem Cells and Its Promises; Conclusion; Considerations for Culturing and Preserving Adult Stem Cells for Therapeutics; Introduction; Cryopreservation; Freshly Isolated Versus Culture-Expanded Cells; Temperature and Rate of Cooling; DMSO Toxicity; Animal Serum-Free Culture and Growth Factors; Oxygen Conditions |
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Critical Role of Oxygen in Stem-Cell FunctionalityStrategies Used for Hypoxic Culturing; Oxygen Requirements to Prepare Stem Cells for Clinical Therapy; Conclusion; References; Bioinformatics Toolbox for Stem Cell Research and Therapeutics; Introduction; Transcriptomics-Based Databases and Tools; StemCellDB: The Human Pluripotent Stem Cell Database; PluriTest; StemBase; The Stem Cell Discovery Engine; Multiple Level-Based Databases and Tools; ESCAPE; SyStemCell; Stem Cell Omics Repository; References; Part II Stem Cells and Organ Systems: Nervous System |
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Stem Cell Therapy for Neurological Disorders: From Bench to BedsideIntroduction; Neurological Disorders; Alzheimer's Disease; Epidemiology and Pathology; Disease Susceptibility; Parkinson's Disease; Epidemiology and Pathology; Disease Susceptibility; Huntington's Disease; Multiple Sclerosis; Epidemiology and Pathology; Disease Susceptibility; Amyotrophic Lateral Sclerosis; Epidemiology and Pathology; Disease Susceptibility; Stem Cell Therapy for Neurological Disease -- Introduction; Generating iPS Cell Lines to Study Neurological Disease; Genome Editing; Direct Conversion |
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Differentiation Protocols to Model Selected Neurogenerative DiseasesExisting and Future Therapies Using Adult Stem Cells; Foetal Cells -- A Case Study from Parkinson's Disease ; Advantages and Disadvantages of Using Stem Cell Therapy in the Treatment of Neurological Disorders; Advantages; Challenges; Results From the Bench; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Amyotrophic Lateral Sclerosis; Stem Cell Therapy: Readiness to the Bedside I; Parkinson's Disease; Stem Cell Therapy: Readiness to the Bedside II; Multiple Sclerosis; Conclusion; References |
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Stem Cells and Neuronal DifferentiationBirth of a Neuron; Differentiation and Specification of Neuroepithelial Cells; Isolation of Neural Stem Cells (NSCs); Differentiation of NSCs to Neuronal Cells; Differentiation of Human Embryonic Stem Cells to Neuronal Cells; Differentiation of Human-Induced Pluripotent Stem Cells (iPSCs) to Neuronal Cells; Direct Reprogramming of Fibroblasts to Induced NSCs (iNSCs) or Neural Progenitors (iNPs); Differentiation of Mesenchymal Stem Cells; In Vitro Neuronal Differentiation of MSCs; Neuronal Differentiation Using Extrinsic Cues |
| Summary |
The book Stem Cell Therapy for Organ Failures edited by Dr. S. Indumathi demonstrates the in vitro and in vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells have ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remains a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics |
| Analysis |
celbiologie |
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cellular biology |
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stamcellen |
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stem cells |
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biomedische wetenschappen |
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biomedicine |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
English |
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Online resource; title from PDF title page (SpringerLink, viewed January 16, 2015) |
| In |
Springer eBooks |
| Subject |
Stem cells -- Therapeutic use
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Stem cells.
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Stem Cells
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Stem cells
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medicines (material)
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| Form |
Electronic book
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| Author |
Somasundaram, Indumathi, editor
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| ISBN |
9788132221104 |
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8132221109 |
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8132221095 |
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9788132221098 |
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