Title Inflammation-associated depression : evidence, mechanisms and implications / Robert Dantzer, Lucile Capuron, editors

Published [Place of publication not identified] : Springer, 2017

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Description 1 online resource (x, 356 pages) : illustrations Series Current topics in behavioral neurosciences, 1866-3370 ; volume 31 Current topics in behavioral neurosciences ; 31. Contents Preface; Contents; Evidence for Inflammation-Associated Depression; 1 Introduction; 2 Evidence from Animal Models; 3 Evidence from Clinical Studies; 3.1 Cytokines and Cell-Mediated Immune (CMI) Pathways Contribute to Inflammation and Depression; 3.2 Platelet-Activating Factors (PAFs) and Oxidative and Nitrosative Stress (OandNS) Contribute to Inflammation and Depression; 3.3 Damage to Mitochondria and Mitochondrial DNA Contribute to Inflammation and Depression; 4 Discussion; 5 Conclusion; References Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms1 Inflammation and Neuropsychiatric Symptoms; 1.1 From Sickness to Neuropsychiatric Disorders; 1.2 Towards the Identification of Common Major Symptom Domains Targeted by Inflammatory Processes; 1.3 Evidence for a Role of Inflammation in Distinct Neuropsychiatric Domains; 2 Inflammation and the Specificity of Neuropsychiatric Symptoms Units; 2.1 A Multimodal Biological Substrate; 2.2 Vulnerability and Modulatory Factors; The HPA Axis and Its Relation to Stress; Metabolic Abnormalities Personality3 Conclusion and Therapeutic Implications; References; Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease; 1 Introduction; 2 Epidemiology; 2.1 Depressive Illness; 2.2 Cardiovascular Disease; 2.3 Co-morbidity Between DI and Cardiovascular Disease; 3 Factors Accountable for the Co-morbidity; 3.1 Role of Stress in Inflammation and Depression; 3.2 Autonomic Nervous System Dysfunction; 3.3 Heart Rate Variability; 4 Bidirectionality of Inflammation in Cardiovascular Disease and Depression; 4.1 Inflammation and Depression 4.2 Inflammation and Cardiovascular Disease4.3 C-Reactive Protein; 4.4 Endothelial Dysfunction; 5 The Tryptophan/Kynurenine Pathway: Implications for Serotonergic Transmission; 6 Inflammation and the Serotonin Transporter; 7 The Glutamatergic Theory of Depression; 8 Other Mechanisms; 9 Treatment Issues; 10 Concluding Remarks; References; Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression; 1 Periphery-to-Brain Communication Pathways; 1.1 Neural Pathway; 1.2 Signaling via Cerebral Endothelial Cells; 1.3 Signaling via the Circumventricular Organs 1.4 Peripheral Immune-Cell-to-Brain Signaling2 Changes in Brain Function as a Result of Periphery-to-Brain Communication; 3 Gut Microbiome, Systemic Inflammation, and Altered Behavior and Mood; 3.1 Gut Microbiome and Changes During Inflammatory Diseases; 3.2 Gut-to-Brain Communication Can Modulate Behavior; 3.3 Changes in Gut Microbiome Can Modulate Systemic Inflammation and Thereby Behavior; 3.4 Gut Dysbiosis in Systemic Disease; 4 Concluding Remarks; References; Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms; 1 Introduction Summary Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book ℓ́ℓInflammation-Associated Depressionℓ́ℓ is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level Bibliography Includes bibliographical references at the end of each chapters Subject Depression, Mental. Inflammation. Depressive Disorder -- physiopathology Depressive Disorder Depression Inflammation Psychopharmacology. Immunology. Health psychology. Neurosciences. HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Depression, Mental Inflammation Form Electronic book Author Dantzer, Robert. Capuron, Lucile ISBN 9783319511528 3319511521

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