Title Lung cancer : treatment and research / Karen L. Reckamp, editor

Published Switzerland : Springer, 2016

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Description 1 online resource (vi, 322 pages) : illustrations (some color) Series Cancer treatment and research ; volume 170 Cancer treatment and research ; volume 170 Contents 1 Lung Cancer Screening; Abstract; 1 Why Screen for Lung Cancer?; 2 Screening with Chest X-Ray and Sputum Cytologic Studies; 3 Screening with Low-Dose CT of the Chest; 4 Benefits and Risks of LDCT Screening; 5 Guidelines for LDCT Screening; 6 Conclusions; References; 2 Diagnosis and Molecular Classification of Lung Cancer; Abstract; 1 Introduction; 2 Histological Classification of NSCLC; 2.1 Adenocarcinoma (ADC); 2.2 Squamous Cell Carcinoma (SqCC); 2.3 Large-Cell Lung Carcinoma (LCLC); 3 Molecular Alterations of NSCLC; 3.1 Epidermal Growth Factor Receptor (EGFR) 3.2 Anaplastic Lymphoma Kinase (ALK)3.3 Human Epidermal Growth Factor Receptor 2 (HER2); 3.4 ROS Proto-Oncogene 1, Receptor Tyrosine Kinase (ROS); 3.5 Ret Proto-Oncogene (RET); 3.6 NTRK1 (TrkA) Fusions; 3.7 MET; 3.8 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS); 3.9 B-Raf Proto-Oncogene, Serine/Threonine Kinase (BRAF); 3.10 Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS); 3.11 v-AKT Murine Thymoma Viral Oncogene Homolog 1 (AKT1); 3.12 Mitogen-Activated Protein Kinase 1 (MAP2K1); 3.13 Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Alpha (PIK3CA) 4 Diagnostic and Molecular Testing of NSCLC4.1 Pathological Diagnosis of NSCLC; 4.1.1 Thyroid Transcription Factor 1 (TTF-1); 4.1.2 p40; 4.1.3 Mucicarmin; 4.2 Molecular Testing of NSCLC; 5 Future Directions: Immunotherapy Revolution and Its Integration with Lung Cancer Diagnostics and Therapy; 6 Conclusions; References; 3 Lung Cancer Staging and Prognosis; Abstract; 1 Lung Cancer Overview; 2 Lung Cancer Staging; 2.1 History of Lung Cancer Staging; 2.2 Non-small Cell Lung Cancer Staging; 2.2.1 IALSC NSCLC TNM Descriptors; 2.2.2 Synchronous Tumor Nodules; 2.3 Pulmonary Carcinoid Tumor Staging 2.4 Small Cell Lung Cancer Staging3 Prognosis; 3.1 Stage-Based Survival Outcomes; 3.2 Clinical and Demographic Prognostication; 3.3 Biomarkers and Genetic Prognostic Indicators; 3.4 Predictive Biomarkers; 3.5 Immunotherapy and Prognosis; 3.6 The Future of NSCLC Prognostication; References; 4 Surgical Treatment of Lung Cancer; Abstract; 1 Introduction; 2 Preoperative Evaluation; 2.1 Radiographic Staging; 2.2 Tissue Diagnosis; 2.3 Physiologic Pulmonary Evaluation; 2.4 Cardiac Evaluation; 2.5 Mediastinal Staging; 3 Surgery and Small-Cell Lung Cancer (SCLC); 4 Non-Small-Cell Lung Cancer (NSCLC) 4.1 Stage IA4.2 Stage IB; 4.3 Stage IIB; 4.4 Stage III NSCLC; 4.4.1 Stage IIIA (e.g., T3N1/T4N1); 4.4.2 Stage IIIA with N2 Disease; 4.5 Stage IIIB and IV NSCLC; 4.6 Special Situations; 4.6.1 Extended Resections; 4.6.2 Synchronous NSCLC; 4.6.3 Oligometastatic Disease; 5 Surgical Options and Approaches; 5.1 Types of Incisions; 5.2 Types of Surgical Resection; 5.2.1 Wedge Resection; 5.2.2 Segmentectomy; 5.2.3 Lobectomy; 5.2.4 Pneumonectomy; 5.2.5 Sleeve Resections; 5.2.6 Carinal Resection; 6 Summary; Bibliography; 5 Treatment: Radiation Therapy; Abstract; 1 Stage I-II Disease Summary This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer Notes Online resource; title from PDF title page (SpringerLink, viewed August 29, 2016) Subject Lungs -- Cancer -- Treatment Lung Neoplasms -- therapy Cardiothoracic surgery. Radiotherapy. Oncology. HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Lungs -- Cancer -- Treatment Form Electronic book Author Reckamp, Karen L., editor. ISBN 9783319403892 3319403893

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