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E-book

Title Severe asthma : toward personalized patient management / Yong Chul Lee, So Ri Kim, Seong Ho Cho, editors
Published Singapore : Springer, ©2018

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Description 1 online resource (135 pages)
Contents Preface -- Contents -- List of Contributors -- Part I: Overview of Severe Asthma -- 1: Basics of Severe Asthma in Clinical Practice -- 1.1 Definition of Severe Asthma -- 1.2 Epidemiology and Clinical Significance of Severe Asthma -- 1.3 Specific Considerations in Severe Asthma -- 1.3.1 Fungal Sensitization/Allergy- Associated Clinical Conditions -- 1.4 Conditions Mimicking Severe Asthma -- References -- 2: Heterogeneity in Severe Asthma -- 2.1 Asthma-COPD Overlap Syndrome and Smoking Asthmatics in Severe Asthma -- 2.1.1 Definition
2.1.2 Prevalence2.1.3 Influence of Tobacco Smoking in Asthma -- 2.1.4 Management and Future of ACOS -- 2.2 Comorbid Conditions of Severe Asthma -- 2.2.1 Respiratory Infections -- 2.2.2 Rhinitis and Rhinosinusitis -- 2.2.3 Gastroesophageal Reflux Disease (GERD) -- 2.2.4 Obesity and Obstructive Sleep Apnea (OSA) -- 2.2.5 Psychopathologies and Breathing Dysfunction -- 2.3 Allergic Bronchopulmonary Aspergillosis and Severe Asthma -- 2.3.1 Prevalence -- 2.3.2 Historical Preview -- 2.3.3 Aspergillus and Relationship with Asthma
2.3.4 Pathophysiology2.3.5 Clinical Features and Diagnosis -- 2.3.6 Radiologic Findings -- 2.3.7 Histopathologic Findings -- 2.3.8 Treatment -- 2.3.8.1 Glucocorticosteroids (GCs) -- 2.3.8.2 Antifungal Agents -- 2.3.8.3 Biologics -- 2.4 Aspirin-Exacerbated Respiratory Disease and Severe Asthma -- 2.4.1 Historical Preview -- 2.4.2 Prevalence and Presentations -- 2.4.3 Diagnosis -- 2.4.4 Pathogenesis -- 2.4.5 Management and Medications -- 2.4.6 Aspirin Desensitization -- 2.4.7 Surgery -- References
Part II: Pathobiology of Severe Asthma3: Pathogenesis of Severe Asthma -- 3.1 Structural Abnormalities and Airway Remodeling -- 3.1.1 Alterations of Bronchial Epithelium -- 3.1.2 Proliferation and Hypertrophy of Airway Smooth Muscle (ASM) -- 3.1.3 Fibrosis, Subepithelial Thickening, and Alternation of ECM -- 3.1.4 Vascularity and Vascular Permeability -- 3.2 Corticosteroid Resistance and Its Molecular Mechanisms -- 3.2.1 Genetic Association -- 3.2.2 Functional Changes of GRs -- 3.2.3 GR Isoform Identity and Expression
3.2.4 Pro-inflammatory Transcription Factor Activation3.2.5 Defective Histone Acetylation -- 3.2.6 Immune Mechanisms -- 3.3 Type 2 Inflammation -- 3.3.1 T Helper Type 2 (Th2) Cell- Dependent Inflammations -- 3.3.2 Innate Lymphoid Type 2 Cell-Associated Inflammation -- 3.4 Non-type 2 Inflammation -- 3.4.1 Inflammasome -- 3.4.2 TNF-α -- 3.4.3 Th17 Cell-Dependent Inflammation -- 3.4.4 Infection and IFN-γ -- 3.5 Subcellular Organelles -- 3.5.1 Endoplasmic Reticulum (ER) -- 3.5.2 Mitochondrial Dysfunction -- References
Summary This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients' symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff
Notes ""Part III: Diagnostic Approaches to Severe Asthma""
Includes index
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Asthma -- Diagnosis.
Asthma -- Treatment
Asthma -- therapy
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Asthma -- Diagnosis
Asthma -- Treatment
Form Electronic book
Author Lee, Yong Chul
Kim, So Ri
Cho, Seong Ho
ISBN 9789811019982
9811019983
9811019975
9789811019975