| Description |
1 online resource : color illustrations |
| Contents |
Intro; Foreword; Preface; Why Oral Cancer Detection Is Challenging?; How Emerging Technology Simplifies Detection?; The Future of the Field!; Contents; 1: Introduction to Oral Cancer; 1.1 Introduction; 1.2 Risk Factors; 1.2.1 Tobacco, Alcohol, and Areca Alkaloids; 1.2.2 Age and Nutritional Deficiency; 1.2.3 Viruses; 1.2.4 Trauma and Inflammation; 1.2.5 Mouthwash and Toothpaste; 1.2.6 Candida; 1.2.7 Solar Radiation; 1.3 Oral Potentially Malignant Disorders (OPMD); 1.4 Group I: Habit-Associated conditions (Major Category); 1.4.1 Leukoplakia; 1.4.2 Oral Submucous Fibrosis |
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1.4.3 Erythroplakia1.4.4 Palatal Lesions Associated with Reverse Smoking; 1.5 Group II: Inflammatory, Immune-Mediated Lesions; 1.5.1 Oral Lichen Planus; 1.5.2 Discoid Lupus Erythematosus; 1.6 Group III: Lesions Secondary to Solar Radiation; 1.6.1 Actinic Keratosis; 1.7 Group IV: Infections; 1.7.1 Oral Syphilis; 1.7.2 Chronic Candidiasis; 1.8 Group IV: Rare Inherited Disorders (Minor Category); 1.8.1 Dyskeratosis Congenita (DC); 1.9 Oral Squamous Cell Carcinoma; 1.9.1 Basic Histological Observations; 1.9.1.1 Dysplasia; 1.9.1.2 Carcinoma In Situ |
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1.9.2 Grading and Staging of OSCC1.10 Field Cancerization and Cancer Stem Cell Hypothesis; 1.10.1 Oral Cancer Stem Cells; References; 2: Genetics and Molecular Mechanisms in Oral Cancer Progression; 2.1 Introduction; 2.2 Genetic Signature of Oral Cancer; 2.3 Molecular Mechanisms of OSCC Development and Progression; 2.3.1 Proto-oncogenes; 2.3.1.1 Growth Factor Receptors; 2.3.1.2 Rat Sarcoma Viral Oncogene (RAS); 2.3.1.3 MYC; 2.3.2 Tumor Suppressor Genes; 2.3.2.1 Tumor Protein p53 (TP53); 2.3.2.2 Retinoblastoma (RB1); 2.3.2.3 Fragile Histidine Triad (FHIT) |
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2.3.2.4 Von Hippel-Lindau (VHL) Disease2.3.2.5 Adenomatous Polyposis Coli (APC); 2.3.3 Epigenetic Alterations in Oral Cancer; 2.4 Noncoding RNAs: Novel Players in Oral Cancer; 2.4.1 MicroRNAs; 2.4.2 Oncogenic MicroRNAs; 2.4.2.1 miR-21; 2.4.2.2 miR-31; 2.4.2.3 miR-146a; 2.4.2.4 miR-134; 2.4.2.5 miR-144; 2.4.2.6 miR-184; 2.4.2.7 miR-7; 2.4.2.8 miR-127; 2.4.2.9 miR-518c-5p; 2.4.3 MicroRNAs as Tumor Suppressors; 2.4.3.1 miR-200 Family; 2.4.3.2 miR-101; 2.4.3.3 miR-26a/b; 2.4.3.4 miR-137; 2.4.3.5 miR-125a; 2.4.3.6 miR-491-5p; 2.4.3.7 miR-29a; 2.4.3.8 miR-124; 2.4.3.9 miR-218 |
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2.4.3.10 miR-99 Family2.4.3.11 miR-375; 2.4.3.12 miR-204; 2.4.4 Piwi-Interacting RNA; 2.4.5 Circular RNAs; 2.4.6 Long Noncoding RNA: Novel and Undisputable Players; 2.4.6.1 HOX Antisense Intergenic RNA (HOTAIR); 2.4.6.2 FOXC1 Upstream Transcript, Noncoding (FOXCUT); 2.4.6.3 Metastasis-Associated Lung Adenocarcinoma Transcript-1 (MALAT1); 2.4.6.4 Urothelial Carcinoma-Associated 1 (UCA 1); 2.4.6.5 Taurine Upregulated Gene 1 (TUG1); 2.4.6.6 Maternally Expressed Gene 3 (MEG3); 2.4.6.7 Long Noncoding RNA Colon Cancer-Associated Transcripts 1 and 2 (CCAT1 and CCAT2) |
| Summary |
This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Mouth -- Cancer -- Diagnosis.
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Mouth Neoplasms -- diagnosis
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Mouth -- Cancer -- Diagnosis
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| Form |
Electronic book
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| Author |
Panta, Prashanth, editor
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| ISBN |
9783319612553 |
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3319612557 |
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9783319612560 |
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3319612565 |
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