The logic of aging -- Genome structure and function -- Genome maintenance -- Genome instability and accerated aging -- The aging genome -- From genome to phenome -- A genomic limit to life?
Summary
Aging has long been ascribed to the gradual accumulation of mutations in the genome. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms resulting from recent advances in functional genomics and systems biology. - ;Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technol
Bibliography
Includes bibliographical references (pages 309-351) and index
