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Title Biological sequence analysis : probalistic models of proteins and nucleic acids / Richard Durbin ... [and others]
Published Cambridge, UK ; New York : Cambridge University Press, 1998


Location Call no. Vol. Availability
 W'PONDS  572.8633 Dur/Bsa  AVAILABLE
Description xi, 356 pages : illustrations ; 26 cm
Contents 1. Introduction -- 2. Pairwise alignment -- 3. Markov chains and hidden Markov models -- 4. Pairwise alignment using HMMs -- 5. Profile HMMs for sequence families -- 6. Multiple sequence alignment methods -- 7. Building phylogenetic trees -- 8. Probabilistic approaches to phylogeny -- 9. Transformational grammars -- 10. RNA structure analysis -- 11. Background on probability
Summary This book provides the first unified, up-to-date, and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis, and phylogenetic inference are treated at length. Written by an interdisciplinary team of authors, the book is accessible to molecular biologists, computer scientists and mathematicians with no formal knowledge of each others' fields. It presents the state-of-the-art in this important, new and rapidly developing discipline
Bibliography Includes bibliographical references (pages 326-344) and indexes
Subject Nucleotide sequence -- Statistical methods.
Amino acid sequence -- Statistical methods.
Numerical analysis.
Author Durbin, Richard.
LC no. 97046769
ISBN 0521620414 (hardcover)
0521629713 (paperback)