| Description |
1 online resource (xvii, 750 pages) : illustrations |
| Series |
Cancer drug discovery and development |
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Cancer drug discovery and development.
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| Contents |
Part I. Genomics, Cancer Targets, Transcriptomics, and Gene Expression Analysis. Genomic Resources for Cancer Biologists / Xuefeng Bruce Ling, Gene Cutler, and Timothy Hoey ; Cancer Drug Target Identification by SAGE, LongSAGE, and Digital Karyotyping / Heiko Hermeking ; Identification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence Databases / Tapan K. Bera, Kristi A. Egland, B.K. Lee, and Ira Pastan ; Tree-Based Cancer Classification and Diagnosis Using Gene Expression Data / Heping Zhang ; From FISH to Proteomics: A Molecular Brush to Define Antitumor Drug Action / Balanehru Subramanian, Alexander Nakeff, and Frederick Valeriote ; Gene Program Signatures for Papillomavirus E2-Mediated Senescence in Cervical Cancer Cells: Finding the Points of No Return / Sarah S. Williams, Bruce J. Aronow, and Susanne I. Wells -- Part II. Advances in Proteomic and Enzymatic Cancer-Profiling Technologies. Mass-Spectrometry-Based Proteomics for Cancer Biology / Chen Xu and John R. Yates III ; Chemical Proteomics in Drug Development / Douglas A. Jeffery, Amos Baruch, and Matthew Bogyo ; Proteomics-Based Anticancer Drug Discovery / K.K. Jain ; Cancer Metabolic Phenotype: Exploiting the Cancer Metabolome in Drug Discovery / John R. Griffiths and Marion Stubbs ; Focusing Target Discovery and Validation Through Proteogenomics and Molecular Imaging / Lucy A. Carver and Jan E. Schnitzer -- Part III. Cancer Target Validation: Cellular Approaches. RNA Interference: RNAid for Future Therapeutics? / Mustapha Diallo, Katja Schmitz, and Ute Schepers ; Image-Based Assays of Cellular Phenotype for Drug Target Discovery and Validation / Kris F. Sachsenmeier and Jonathan A. Terrett ; Targeting Inducible Chemotherapy Resistance Mechanisms in Colon Cancer / David Ljungman and James C. Cusack, Jr. ; Targeting Apoptosis Pathways for Cancer Therapy / Bharvin K.R. Patel |
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Part IV. Cancer Target Validation: Animal Approaches. Genetically Engineered Mouse Models of Human Cancer for Drug Discovery and Development / Rónán C. O'Hagan, Min Wu, William M. Rideout III, Yinghui Zhou, and Joerg Heyer ; Unraveling the Complexity of Oncogenesis Through In Vivo Optical Imaging / Pamela Reilly Contag ; Innovative Strategies for Improving Engineered Mouse Models of Human Cancer for Preclinical Development / Jeffrey J. Martino and Suzie Chen ; Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes / Jeff L. Ellsworth, Andrew Feldhaus, and Steven D. Hughes ; Cancer Biology and Transgenic Technology in the Mouse: Bridging the Functional Gap / Cindy E. McKinney and Cooduvalli S. Shashikant ; Homology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides: PDGF-D / Gary C. Starling, William J. LaRochelle, and Gulshan Ara -- PART V. Cancer Prognostics, Diagnostics, and Biomarkers. Cancer Pharmacogenomics: Predicting Drug Response in the Genomic Era / Brian Z. Ring and Huijun Z. Ring ; Diagnosis and Treatment of Malignancies Using Gene Expression Profiling / Jimmy C. Sung, Alice Y. Lee, and Timothy J. Yeatman ; Implications of Epigenetics for Early Cancer Diagnosis and Prevention / Mukesh Verma and Sudhir Srivastava ; Novel Molecular and Genetic Prognostic Biomarkers in Prostate Cancer / Arnab Chakravarti and Gary Guotang Zhai ; PSA in Prostate Cancer Diagnosis / Pradip Datta ; Tumor Targets and Biomarkers in Renal Cell Carcinoma / Ivar Bleumer and Peter F.A. Mulders -- PART VI. Emerging Approaches to Cancer Therapy: VI-A. Targeting the Vasculature. Tumor Vasculature as a Target for Cancer Therapy / Grzegorz Korpanty, Xianming Huang, and Rolf A. Brekken ; Targeting the VEGF/VEGFR Axis for Cancer Therapy / Frank A. Scappaticci ; Inhibiting Cancer Angiogenesis With Molecular Therapy / Qixin Leng and A. James Mixson -- VI-B. Supportive and Adjuvant Therapies. Development of Palifermin (rHuKGF) for Mucositis / Ping Wei and Catherine L. Farrell ; Immune Modulation: The B7 Family Cosignaling Molecules as Emerging Targets for Enhancing Cancer Therapy / Sheng Yao and Lieping Chen -- VI-C. Tumor-Targeted Therapies. Proteasome Inhibition and Its Clinical Application in Solid Tumors / David J. Park and Heinz-Josef Lenz ; Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy / Anas Younes and Andrea Cerutti ; Small-Molecule Receptor Tyrosine Kinase Inhibitors in Targeted Cancer Therapy / Carlos García-Echeverría ; The mTOR Pathway and Its Inhibitors / John B. Easton and Peter J. Houghton ; Cyclo-Oxygenase-2 Enzyme and Its Inhibition in Tumor Growth and Therapy / Zhongxing Liao, Uma Raju, Kathryn A. Mason, and Luka Milas ; Understanding Prostate-Specific Membrane Antigen and Its Implication in Prostate Cancer / Arundhati Ghosh and Warren D.W. Heston ; Development of a Radiolabeled Monoclonal Antibody to Prostate-Specific Membrane Antigen / Stanley J. Goldsmith, Shankar Vallabhajosula, Matthew I. Milowsky, David M. Nanus, Lale Kostakoglu, and Neil H. Bander ; Monoclonal Antibody Strategies for Targeting HER2 / Joan Albanell, Jeffrey S. Ross, Linda Pronk, and Pere Gascon ; From XenoMouse Technology to Panitumumab (ABX-EGF) / Xiaodong Yang, Lorin Roskos, C. Geoffrey Davis, and Gisela Schwab ; Development and Evaluation of Cancer Therapeutic Agents Targeting TRAIL Receptor 1 and 2 / Robin C. Humphreys ; Clinical Studies of Immunotherapy With Rituximab (Rituxan) and Radioimmunotherapy With Ibritumomab Tiuxetan (Zevalin) in B-Cell Lymphoid Malignancies / Arturo Molina -- PART VII. Informatics Strategies and Initiatives. Informatics Strategies and Initiatives Used in Cancer Research / Martin D. Leach |
| Summary |
This is an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue an |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Cancer -- Genetic aspects -- Handbooks, manuals, etc
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Oncogenes -- Handbooks, manuals, etc
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Genomics -- Handbooks, manuals, etc
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Proteomics -- Handbooks, manuals, etc
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Genomics.
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Genomics
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Neoplasms -- genetics
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Oncogenes -- genetics
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Cancer -- Genetic aspects.
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Oncogenes.
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Genomics.
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Proteomics.
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Cancer -- Genetic aspects
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Genomics
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Oncogenes
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Proteomics
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| Genre/Form |
handbooks.
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Handbooks and manuals
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| Author |
Larochelle, William J
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Shimkets, Richard A.
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| LC no. |
2004027753 |
| ISBN |
9781592598939 |
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1592598935 |
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1588294250 |
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9781588294258 |
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