| Description |
1 online resource (xix, 696 pages) : illustrations (chiefly color) |
| Contents |
Foreword; Acknowledgments; Introductory Commentary; References; Contents; Part I: Overview; 1: The Optimization of Natural Healing; 1.1 Introduction; 1.2 The Phases of Tissue Healing; 1.2.1 Hemostasis Phase; 1.2.2 Inflammation Phase; 1.2.3 Proliferation Phase; 1.2.4 Remodeling Phase; 1.3 Impaired Tissue Healing; 1.4 Factors That Contribute to Impaired Healing; 1.4.1 Obesity; 1.4.2 Drugs; 1.5 Factors That Improve Natural Healing; 1.5.1 Sleep; 1.5.2 Circadian Rhythms; 1.5.3 Nutrition; 1.5.4 Dietary Supplements; 1.5.5 Physical Activity; 1.5.6 Cognitive Control/Biofeedback |
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4.2.1 The Food and Drug Administration4.2.2 Regulatory Overview; 4.2.3 The Three-Tiered Approach; 4.2.4 Alternative Pathways; 4.2.5 Case Example of Carticel; 4.3 Regulation of Orthobiologics Around the World; 4.3.1 Europe; 4.3.2 Australia; 4.3.3 Canada; 4.3.4 Russia; 4.3.5 India; 4.3.6 Mexico; 4.3.7 China; 4.3.8 Japan; 4.4 Stem Cell Tourism; 4.4.1 A Direct-to-Consumer Industry; 4.4.2 Domestic Tourism; 4.4.3 Dubious Practices; 4.5 The REGROW Act; 4.6 Reimbursement; 4.6.1 Coverage and Reimbursement in the United States; 4.6.2 Reimbursement of Orthobiologics in the EU |
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4.7 Conclusion4.8 Cell Therapy Regulatory Toolkit; References; 5: Tissue Engineering and New Biomaterials; 5.1 Native Extracellular Matrix as a Host; 5.2 Humoral Response to a Scaffold; 5.2.1 Blood Material Interaction and Biofilm Formation; 5.2.2 Acute Inflammation; 5.2.3 Chronic Inflammation; 5.2.4 Granulation Tissue Formation, Foreign Body Reaction, and Tissue Encapsulation; 5.3 Signaling; References; 6: Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches; 6.1 Introduction |
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6.2 Physiology and Homeostasis of Musculoskeletal Structures6.2.1 Tendon; 6.2.2 Ligament; 6.2.3 Bone; 6.2.4 Skeletal Muscle; 6.2.5 Articular Cartilage and Fibrocartilage; 6.3 Injury Response, Healing Process, and Subsequent Diseases; 6.3.1 Biomarkers; 6.3.2 Osteoarthritis; 6.4 Regenerative Medicine Approaches; 6.4.1 Autologous Biologic Therapies; 6.4.2 Gene Therapy; 6.4.3 Stem Cells; 6.4.4 Tissue Engineering; 6.4.5 Anti-fibrotic therapy; 6.5 Conclusions and Future Directions; References |
| Summary |
This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Orthopedics.
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Stem cells -- Therapeutic use
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Biomechanics.
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Orthopedic surgery.
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Orthopedic Procedures
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Orthopedics
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Biomechanical Phenomena
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Orthopedic surgery
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Biomechanics
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Orthopedics
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| Form |
Electronic book
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| Author |
Gobbi, Alberto.
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| ISBN |
9783662541814 |
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3662541815 |
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