| Description |
1 online resource (270 pages) |
| Contents |
THE BIOSTATISTICS OF AGING: From Gompertzian Mortalitytoan Index of Aging-Relatedness; Copyright; CONTENTS; PREFACE AND ACKNOWLEDGMENT; 1 Introduction; 2 An Account of Gompertzian Mortality through Statisticaland Evolutionary Arguments; 2.1 The Statistical Theory of Extreme Values; 2.1.1 Background to Results; 2.1.2 Original Results; 2.2 The Evolutionary Theory of Aging; 2.2.1 The Argument for Gompertzian Mortality; 2.2.2 Boundaries of the Argument; 3 The Argument against Gompertzian Mortality; 3.1 Departures from the Gompertz Model; 3.2 An Evolution-Based Model of Causation |
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4 The Index of Aging-Relatedness4.1 A Survival Mixture Model of the Gompertz and WeibullDistributions; 4.2 Definition and Interpretation of the Index of Aging-Relatedness; 4.3 The Survival Mixture Model and Competing Risks; 4.4 Estimation of the Model Parameters; 4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study; 4.6 Precision of Estimation; 5 Discussion: Implications; 5.1 The Meaning of the Gompertz Parameter; 5.2 Age as a Risk Factor for Disease; 5.3 Are Aging-Related Diseases an Integral Part of Aging?; 5.4 Biological versus Chronological Aging |
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5.5 The Public Health Notion of Compression of Morbidity5.6 A Picture of Aging for the Twenty-First Century; APPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITHSOME EXTENSIONS; APPENDIX B: DERIVATION OF HAMILTON'S EQUATIONFOR THE FORCE OF NATURAL SELECTIONON MORTALITY; APPENDIX C: SOME PROPERTIES OF THE GOMPERTZ ANDWEIBULL DISTRIBUTIONS; APPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OFTHE MIXTURE LOG-LIKELIHOOD FUNCTION; APPENDIX E: EXPECTATION-CONDITIONAL MAXIMIZATION(ECM) ALGORITHM; APPENDIX F: R PROGRAM; REFERENCES; AUTHOR INDEX; SUBJECT INDEX |
| Summary |
A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion-with consequential biomedical and public health relevance-of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input fr |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Aging -- Statistical methods
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Mortality -- Statistical methods
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Life spans (Biology)
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Life expectancy.
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Mortality.
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Aging -- pathology
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Epidemiologic Methods
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Life Expectancy
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Models, Statistical
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Mortality
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mortality.
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Mortality
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Life expectancy
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Aging -- Statistical methods
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Life spans (Biology)
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Mortality -- Statistical methods
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| Form |
Electronic book
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| Author |
Levin, Bruce
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| ISBN |
9781118645673 |
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1118645677 |
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9781118645857 |
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1118645855 |
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