| Description |
1 online resource (ix, 533 pages) : illustrations (some color) |
| Series |
Advances in experimental medicine and biology, 2214-8019 ; volume 919 |
|
Advances in experimental medicine and biology ; v. 919. 0065-2598
|
| Contents |
Sample preparation strategies for proteomics. Proteomes, their compositions and their sources / Anna Kwasnik, Claire Tonry, Angela Mc Ardle, Aisha Qasim Butt, Rosanna Inzitari [and others] -- Protein fractionation and enrichment prior to proteomics sample preparation / Andrew J. Alpert -- Sample preparation for mass spectrometry-based proteomics; from proteomes to peptides / John C. Rogers, Ryan D. Bomgarden -- Plant structure and specificity: challenges and sample preparation considerations for proteomics / Sophie Alvarez, Michael J. Naldrett -- Improving proteome coverage by reducing sample complexity via chromatography / Uma Kota, Mark L. Stolowitz -- Mass spectrometry for proteomics analysis. Database search engines: paradigms, challenges and solutions / Kenneth Verheggen, Lennart Martens, Frode S. Berven, Harald Barsnes, Marc Vaudel -- Mass analyzers and mass spectrometers / Anthony M. Haag -- Top-down mass spectrometry: proteomics to proteoforms / Steven M. Patrie -- Bioinfomatic tools for proteomics data analysis and interpretation. Platforms and pipelines for proteomics data analysis and management / Marius Cosmin Codrea, Sven Nahnsen -- Tandem mass spectrum sequencing: an alternative to database search engines in shotgun proteomics / Thilo Muth, Erdmann Rapp, Frode S. Berven, Harald Barsnes, Marc Vaudel -- Visualization, inspection and interpretation of shotgun proteomics identification results / Ragnhild R. Lereim, Eystein Oveland, Frode S. Berven, Marc Vaudel, Harald Barsnes -- Protein inference / Zengyou He, Ting Huang, Can Zhao, Ben Teng -- Modification site localization in peptides / Robert J. Chalkley -- Useful web resources / Andre Bui, Maria D. Person -- Mass spectrometry-based protein quantification / Yun Chen, Fuqiang Wang, Feifei Xu, Ting Yang -- Bioinformatics tools for proteomics data interpretation / Karla Grisel Calderón-González, Jesús Hernández-Monge, María Esther Herrera-Aguirre [and others] -- Applications of proteomis technologies in biological and medical sciences. Identification, quantification, and site localization of protein posttranslational modifications via mass spectrometry-based proteomics / Mi Ke, Hainan Shen, Linjue Wang, Shusheng Luo, Lin Lin, Jie Yang, Ruijun Tian -- Protein-protein interaction detection via mass spectrometry-based proteomics / Benedetta Turriziani, Alexander von Kriegsheim, Stephen R. Pennington -- Protein structural analysis via mass spectrometry-based proteomics / Antonio Artigues, Owen W. Nadeau, Mary Ashley Rimmer, Maria T. Villar, Xiuxia Du [and others] -- Introduction to clinical proteomics / John E. Wiktorowicz, Allan R. Brasier -- Clinical proteomics. Discovery of candidate biomarkers / John E. Wiktorowicz, Kizhake V. Soman -- Statistical approaches to candidate biomarker panel selection / Heidi M. Spratt, Hyunsu Ju -- Qualification and verification of protein biomarker candidates / Yingxin Zhao, Allan R. Brasier -- Protocol for standardizing high-to-moderate abundance protein biomarker assessments through an mrm-with-standard-peptides quantitative approach / Andrew J. Percy, Juncong Yang, Andrew G. Chambers, Yassene Mohammed, Tasso Miliotis [and others] |
| Summary |
This volume serves as a proteomics reference manual, describing experimental design and execution. The book also shows a large number of examples as to what can be achieved using proteomics techniques. As a relatively young area of scientific research, the breadth and depth of the current state of the art in proteomics might not be obvious to all potential users. There are various books and review articles that cover certain aspects of proteomics but they often lack technical details. Subject specific literature also lacks the broad overviews that are needed to design an experiment in which all steps are compatible and coherent. The objective of this book was to create a proteomics manual to provide scientists who are not experts in the field with an overview of: 1. The types of samples can be analyzed by mass spectrometry for proteomics analysis. 2. Ways to convert biological or ecological samples to analytes ready for mass spectral analysis. 3. Ways to reduce the complexity of the proteome to achieve better coverage of the constituent proteins. 4. How various mass spectrometers work and different ways they can be used for proteomics analysis 5. The various platforms that are available for proteomics data analysis 6. The various applications of proteomics technologies in biological and medical sciences This book should appeal to anyone with an interest in proteomics technologies, proteomics related bioinformatics and proteomics data generation and interpretation. With the broad setup and chapters written by experts in the field, there is information that is valuable for students as well as for researchers who are looking for a hands on introduction into the strengths, weaknesses and opportunities of proteomics |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from resource home page (SpringerLink, viewed January 26, 2017) |
| Subject |
Proteomics.
|
|
Proteomics -- methods
|
|
Proteomics
|
|
Proteins.
|
|
Molecular biology.
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Proteomics
|
| Form |
Electronic book
|
| Author |
Mirzaei, Hamid, editor.
|
|
Carrasco, Martin (Scientist), editor.
|
| ISBN |
9783319414485 |
|
3319414488 |
|
