| Description |
xviii, 506 pages : illustrations ; 29 cm |
| Contents |
Molecular diagnostics : past, present, and future / G.P. Patrinos, P. Danielson, W.J. Ansorge -- Describing DNA variants (mutation nomenclature) / J.T. den Dunnen, P.E.M. Taschner -- Low- and medium-throughput variant detection methods : a historical perspective / A. Sgourou [and 3 others] -- Quantitative polymerase chain reaction / L. Overbergh [and 3 others] -- Integrated polymerase chain reaction technologies (sample-to-answer technologies) / P.B. Danielson, H.E. McKiernan, K.M. Legg -- High-resolution melting curve analysis for molecular diagnostics / J.S. Farrar, C.T. Wittwer -- Molecular techniques for DNA methylation studies / J. Tost, I.G. Gut -- Perspectives for future DNA sequencing techniques and applications / W.J. Ansorge, T. Katsila, G.P. Patrinos -- Advanced personal genome sequencing as the ultimate diagnostics test / B.A. Peters [and 4 others] -- Application of padlock and selector probes in molecular medicine / I. Hernández-Neuta [and 10 others] -- Advances in microfluidics and lab-on-a-chip technologies / H. Jayamohan [and 6 others] -- Protein diagnostics by proximity ligation : combining multiple recognition and DNA amplification for improved protein analyses / G. Cane [and 9 others] -- Application of proteomics to medical diagnostics / K.M. Legg, H. McKiernan, N. Reisdorph -- Molecular cytogenetics in molecular diagnostics / H. Tönnies -- Cytogenomics of solid tumors by next-generation sequencing : a clinical perspective / D. Sie [and 3 others] -- Pharmacogenomics in clinical care and drug discovery / E. Mendrinou [and 4 others] -- Nutrigenomics : integrating genomic approaches into nutrition research / M.P.G. Barnett, L.R. Ferguson -- DNA microarrays and genetic testing / A. Deshpande, P.S. White -- Bioinformatics tools for data analysis / L. Koumakis, C. Mizzi, G. Potamias -- Genomic databases : emerging tools for molecular diagnostics / G.P. Patrinos [and 3 others] -- Molecular diagnostic applications in forensic science / H.E. McKiernan, P.B. Danielson -- New perspectives in mass disaster victim identification assisted by DNA typing and forensic genomics / D. Corach -- Preimplantation genetic diagnosis / M. De Rycke, C. Staessen -- Noninvasive cell-free DNA prenatal testing for fetal aneuploidy in maternal blood / V. Velissariou, P.C. Patsalis -- Genetic testing and psychology / S.R. Brand, A.F. Patenaude -- Genomic medicine in developing countries and resource-limited environments / T. Katsila [and 10 others] -- Public understanding of genetic testing and obstacles to genetics literacy / K. Kampourakis -- Safety and the biorepository / D.S. Atherton [and 4 others] -- Quality assurance in genetic laboratories / E. Dequeker |
| Summary |
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Molecular diagnosis
|
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Genetic screening
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|
Molecular Diagnostic Techniques
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Cytogenetics -- methods
|
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Genetic Testing
|
| Reading List |
HMM202 prescribed text 2024
|
| Author |
Patrinos, George P., editor
|
|
Ansorge, Wilhelm, 1944- editor
|
|
Danielson, Phillip B., editor
|
| LC no. |
2016960092 |
| ISBN |
9780128029718 |
|
0128029714 |
|
